Reactome | THOC2 [nucleoplasm]

THOC2 [nucleoplasm]

Stable Identifier

R-BTA-8849134

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

THOC2, F1N153

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Bos taurus)

- RNA Polymerase II Transcription (Bos taurus)
  - RNA Polymerase II Transcription Termination (Bos taurus)
    - Cleavage of mRNA at the 3'-end (Bos taurus)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Bos taurus)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Bos taurus)
        
        THO complex [nucleoplasm] (Bos taurus)
        
        THOC2 [nucleoplasm] (Bos taurus)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Bos taurus)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Bos taurus)
        
        THO complex [nucleoplasm] (Bos taurus)
        
        THOC2 [nucleoplasm] (Bos taurus)

Metabolism of RNA (Bos taurus)

- Processing of Capped Intron-Containing Pre-mRNA (Bos taurus)
  - Transport of Mature Transcript to Cytoplasm (Bos taurus)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Bos taurus)
      - NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Bos taurus)
        
        NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Bos taurus)
        
        capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Bos taurus)
        
        TREX (minus DDX39B) [nucleoplasm] (Bos taurus)
        
        THO complex [nucleoplasm] (Bos taurus)
        
        THOC2 [nucleoplasm] (Bos taurus)
        
        polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Bos taurus)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Bos taurus)
        
        THO complex [nucleoplasm] (Bos taurus)
        
        THOC2 [nucleoplasm] (Bos taurus)
  - mRNA 3'-end processing (Bos taurus)
    - Cleavage of mRNA at the 3'-end (Bos taurus)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Bos taurus)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Bos taurus)
        
        THO complex [nucleoplasm] (Bos taurus)
        
        THOC2 [nucleoplasm] (Bos taurus)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Bos taurus)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Bos taurus)
        
        THO complex [nucleoplasm] (Bos taurus)
        
        THOC2 [nucleoplasm] (Bos taurus)
    - mRNA polyadenylation (Bos taurus)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Bos taurus)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Bos taurus)
        
        THO complex [nucleoplasm] (Bos taurus)
        
        THOC2 [nucleoplasm] (Bos taurus)
      - polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Bos taurus)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Bos taurus)
        
        THO complex [nucleoplasm] (Bos taurus)
        
        THOC2 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:F1N153

Gene Names

THOC2

Reference Genes

BioGPS Gene:507738 THOC2

ENSEMBL:ENSBTAG00000008388.6

ENSEMBL:ENSBTAG00000008388.7 THOC2

KEGG Gene (Bos taurus):507738 THOC2

Monarch:507738 THOC2

NCBI Gene:507738 THOC2

Reference Transcript

Other Identifiers

GO:0000347

GO:0000445

GO:0003723

GO:0003729

GO:0005634

GO:0006397

GO:0006406

GO:0006913

GO:0016071

GO:0043226

Participates

as a component of

THO complex [nucleoplasm] (Bos taurus)

Inferred From

THOC2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_005227512.1, NP_001193626.1

OpenTargets

ENSG00000125676

Ensembl

ENSBTAP00000011040, ENSBTAG00000008388, ENSBTAT00000011040