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ERAD complex [endoplasmic reticulum membrane]
Stable Identifier
R-BTA-8866531
Type
Complex
Species
Bos taurus
Compartment
endoplasmic reticulum membrane
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Bos taurus)
ABC-family proteins mediated transport (Bos taurus)
CFTR binds components of the ERAD machinery for ubiquitination and degradation (Bos taurus)
ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Bos taurus)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Bos taurus)
ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
DERL oligomer [endoplasmic reticulum membrane]
(Bos taurus)
ERLIN1:ERLIN2 [endoplasmic reticulum membrane]
(Bos taurus)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment]
(Bos taurus)
RNF5,RNF185 [endoplasmic reticulum membrane]
(Bos taurus)
SEL1L [endoplasmic reticulum membrane]
(Bos taurus)
VCP hexamer [cytosol]
(Bos taurus)
Participates
as an input of
CFTR binds components of the ERAD machinery for ubiquitination and degradation (Bos taurus)
as an output of
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Bos taurus)
as a component of
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
Inferred From
ERAD complex [endoplasmic reticulum membrane]
(Homo sapiens)
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