Reactome | RPL10L [cytosol]

RPL10L [cytosol]

Stable Identifier

R-BTA-8868799

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

RPL10L, Q2TBW8

Locations in the PathwayBrowser

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Metabolism of RNA (Bos taurus)

- Nonsense-Mediated Decay (NMD) (Bos taurus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Bos taurus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Bos taurus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10L [cytosol] (Bos taurus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10L [cytosol] (Bos taurus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Bos taurus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10L [cytosol] (Bos taurus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Bos taurus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10L [cytosol] (Bos taurus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10L [cytosol] (Bos taurus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Bos taurus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10L [cytosol] (Bos taurus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10L [cytosol] (Bos taurus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Bos taurus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Bos taurus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10L [cytosol] (Bos taurus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10L [cytosol] (Bos taurus)
- rRNA processing (Bos taurus)
  - rRNA processing in the nucleus and cytosol (Bos taurus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Bos taurus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10L [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q2TBW8

Gene Names

RPL10L

Reference Genes

BioGPS Gene:538748 RPL10L

ENSEMBL:ENSBTAG00000024582

ENSEMBL:ENSBTAG00000024582.4 RPL10L

KEGG Gene (Bos taurus):538748 RPL10L

Monarch:538748 RPL10L

NCBI Gene:538748 RPL10L

Reference Transcript

RefSeq:NM_001205401.2 RPL10L

Other Identifiers

538748

GO:0003735

GO:0005198

GO:0005634

GO:0005783

GO:0005829

GO:0005840

GO:0006412

GO:0007283

GO:0022414

GO:0022625

GO:0043226

Participates

as a candidate of

RPL10,RPL10L [cytosol] (Bos taurus)

Inferred From

RPL10L [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001192330.1

OpenTargets

ENSG00000165496

Ensembl

ENSBTAG00000024582, ENSBTAT00000007086, ENSBTAP00000007086

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