Reactome | M6PR [clathrin-coated endocytic vesicle membrane]

M6PR [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-BTA-8869100

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

M6PR, P11456

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Bos taurus)

- Membrane Trafficking (Bos taurus)
  - Clathrin-mediated endocytosis (Bos taurus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        M6PR [clathrin-coated endocytic vesicle membrane] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        M6PR [clathrin-coated endocytic vesicle membrane] (Bos taurus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        M6PR [clathrin-coated endocytic vesicle membrane] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        M6PR [clathrin-coated endocytic vesicle membrane] (Bos taurus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        M6PR [clathrin-coated endocytic vesicle membrane] (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        M6PR [clathrin-coated endocytic vesicle membrane] (Bos taurus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        M6PR [clathrin-coated endocytic vesicle membrane] (Bos taurus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        M6PR [clathrin-coated endocytic vesicle membrane] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        M6PR [clathrin-coated endocytic vesicle membrane] (Bos taurus)
    - RAB5 and GAPVD1 bind AP-2 (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        M6PR [clathrin-coated endocytic vesicle membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:P11456

Gene Names

M6PR

Reference Genes

BioGPS Gene:281291 M6PR

ENSEMBL:ENSBTAG00000018207

KEGG:bta:281291 M6PR

Monarch:281291 M6PR

NCBI Gene:281291 M6PR

UCSC:P11456 M6PR

Reference Transcript

RefSeq:NM_175779.3 M6PR

Other Identifiers

281291

GO:0005768

GO:0005770

GO:0007041

GO:0031410

GO:0033299

GO:0043226

GO:0048471

GO:1905394

Participates

as a member of

AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)

Other forms of this molecule

M6PR [plasma membrane]

M6PR [Golgi membrane]

M6PR [lysosomal membrane]

M6PR [trans-Golgi network membrane]

M6PR [transport vesicle]

Inferred From

M6PR [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSBTAT00000024233, ENSBTAP00000088610, ENSBTAP00000024233, ENSBTAG00000018207, ENSBTAT00000091971

VGNC

31125

PDB

2RLB, 1M6P, 1KEO, 1C39, 2RL7, 2RL9, 2RL8, 3K43, 3K42, 3K41, 3CY4

Cite Us!