Reactome | SLC18A3 [clathrin-coated endocytic vesicle membrane]

SLC18A3 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-BTA-8869109

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

SLC18A3, E1BK36

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Bos taurus)

- Membrane Trafficking (Bos taurus)
  - Clathrin-mediated endocytosis (Bos taurus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        SLC18A3 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        SLC18A3 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        SLC18A3 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        SLC18A3 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        SLC18A3 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        SLC18A3 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        SLC18A3 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        SLC18A3 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        SLC18A3 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
    - RAB5 and GAPVD1 bind AP-2 (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        SLC18A3 [clathrin-coated endocytic vesicle membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:E1BK36

Gene Names

SLC18A3

Reference Genes

BioGPS Gene:785833 SLC18A3

ENSEMBL:ENSBTAG00000014990.6

KEGG:bta:785833 SLC18A3

Monarch:785833 SLC18A3

NCBI Gene:785833 SLC18A3

UCSC:E1BK36 SLC18A3

Reference Transcript

Other Identifiers

785833

GO:0005215

GO:0005278

GO:0015311

GO:0051610

GO:0051630

Participates

as a member of

AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)

Other forms of this molecule

SLC18A3 [plasma membrane]

SLC18A3 [clathrin-sculpted acetylcholine transport vesicle membrane]

Inferred From

SLC18A3 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSBTAT00000019955, ENSBTAP00000019955, ENSBTAG00000014990

VGNC

34707

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