Reactome | ATP6V1B2 [cytosol]

ATP6V1B2 [cytosol]

Stable Identifier

R-BTA-912598

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

P31408

Locations in the PathwayBrowser

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Cellular responses to stimuli (Bos taurus)

- Cellular responses to stress (Bos taurus)
  - Cellular response to starvation (Bos taurus)
    - Amino acids regulate mTORC1 (Bos taurus)
      - RRAGA,B exchanges GDP for GTP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
      - RRAGA,B hydrolyzes GTP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
      - RRAGC,D exchanges GTP for GDP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
      - RRAGC,D hydrolyzes GTP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
      - mTORC1 binds RHEB:GTP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)

Immune System (Bos taurus)

- Innate Immune System (Bos taurus)
  - ROS and RNS production in phagocytes (Bos taurus)
    - Intraphagosomal pH is lowered to 5 by V-ATPase (Bos taurus)
      - V-ATPase [phagocytic vesicle membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)

Signal Transduction (Bos taurus)

- Signaling by Receptor Tyrosine Kinases (Bos taurus)
  - Signaling by Insulin receptor (Bos taurus)
    - Insulin receptor recycling (Bos taurus)
      - ATP6AP1 binds V-ATPase (Bos taurus)
        
        V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Bos taurus)
        
        V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
      - Endosome acidification (Bos taurus)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Bos taurus)
        
        V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)

Transport of small molecules (Bos taurus)

- Ion channel transport (Bos taurus)
  - ATP6AP1 binds V-ATPase (Bos taurus)
    - V-ATPase [endosome membrane] (Bos taurus)
      - ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
    - V-ATPase:ATP6AP1 [endosome membrane] (Bos taurus)
      - V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
- Iron uptake and transport (Bos taurus)
  - Transferrin endocytosis and recycling (Bos taurus)
    - ATP6AP1 binds V-ATPase (Bos taurus)
      - V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
      - V-ATPase:ATP6AP1 [endosome membrane] (Bos taurus)
        
        V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)
    - Acidification of Tf:TfR1 containing endosome (Bos taurus)
      - V-ATPase:ATP6AP1 [endosome membrane] (Bos taurus)
        
        V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1B trimer [cytosol] (Bos taurus)
        
        ATP6V1B [cytosol] (Bos taurus)
        
        ATP6V1B2 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:P31408

Reference Genes

BioGPS Gene:338082

ENSEMBL:ENSBTAG00000018646

ENSEMBL:ENSBTAG00000018646.6

KEGG Gene (Bos taurus):338082

Monarch:338082

NCBI Gene:338082

Reference Transcript

Other Identifiers

338082

GO:0000221

GO:0001726

GO:0005215

GO:0005524

GO:0005737

GO:0005773

GO:0005829

GO:0005886

GO:0005902

GO:0016192

GO:0016324

GO:0033180

GO:0043226

GO:0043231

GO:0046034

GO:0046961

GO:0055085

GO:0055086

GO:0097401

GO:0140657

GO:1901135

GO:1902600

Participates

as a member of

ATP6V1B [cytosol] (Bos taurus)

Inferred From

ATP6V1B2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001001146.1, NP_788844.2

Ensembl

ENSBTAG00000018646, ENSBTAT00000024812, ENSBTAP00000024812

VGNC

26318

PDB

6XBW, 7UNE, 6XBY, 7KHR

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