Reactome | ATP6V1A [cytosol]

ATP6V1A [cytosol]

Stable Identifier

R-BTA-912602

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

P31404

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Bos taurus)

- Cellular responses to stress (Bos taurus)
  - Cellular response to starvation (Bos taurus)
    - Amino acids regulate mTORC1 (Bos taurus)
      - RRAGA,B exchanges GDP for GTP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
      - RRAGA,B hydrolyzes GTP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
      - RRAGC,D exchanges GTP for GDP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
      - RRAGC,D hydrolyzes GTP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
      - mTORC1 binds RHEB:GTP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        v-ATPase [lysosomal membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)

Signal Transduction (Bos taurus)

- Signaling by Receptor Tyrosine Kinases (Bos taurus)
  - Signaling by Insulin receptor (Bos taurus)
    - Insulin receptor recycling (Bos taurus)
      - ATP6AP1 binds V-ATPase (Bos taurus)
        
        V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Bos taurus)
        
        V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
      - Endosome acidification (Bos taurus)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Bos taurus)
        
        V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)

Transport of small molecules (Bos taurus)

- Ion channel transport (Bos taurus)
  - ATP6AP1 binds V-ATPase (Bos taurus)
    - V-ATPase [endosome membrane] (Bos taurus)
      - ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
    - V-ATPase:ATP6AP1 [endosome membrane] (Bos taurus)
      - V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
- Iron uptake and transport (Bos taurus)
  - Transferrin endocytosis and recycling (Bos taurus)
    - ATP6AP1 binds V-ATPase (Bos taurus)
      - V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
      - V-ATPase:ATP6AP1 [endosome membrane] (Bos taurus)
        
        V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)
    - Acidification of Tf:TfR1 containing endosome (Bos taurus)
      - V-ATPase:ATP6AP1 [endosome membrane] (Bos taurus)
        
        V-ATPase [endosome membrane] (Bos taurus)
        
        ATP6V1 [cytosol] (Bos taurus)
        
        ATP6V1A trimer [cytosol] (Bos taurus)
        
        ATP6V1A [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:P31404

Reference Genes

BioGPS Gene:282147

ENSEMBL:ENSBTAG00000002703

ENSEMBL:ENSBTAG00000002703.5

KEGG Gene (Bos taurus):282147

Monarch:282147

NCBI Gene:282147

Reference Transcript

Other Identifiers

282147

GO:0000166

GO:0000221

GO:0003824

GO:0005215

GO:0005524

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0005886

GO:0006811

GO:0006879

GO:0015986

GO:0016020

GO:0016787

GO:0016874

GO:0016887

GO:0030133

GO:0030665

GO:0031410

GO:0033180

GO:0036295

GO:0043226

GO:0045851

GO:0046034

GO:0046933

GO:0046961

GO:0055065

GO:0055085

GO:0055086

GO:0140657

GO:1901135

GO:1902600

Participates

as a component of

ATP6V1A trimer [cytosol] (Bos taurus)

Inferred From

ATP6V1A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_776929.1, XP_015326478.1

IntEnz

7.1.2.2

Ensembl

ENSBTAG00000002703, ENSBTAT00000068126, ENSBTAP00000070089

VGNC

26316

PDB

6XBY, 7UNE, 7KHR, 6XBW

Cite Us!