Reactome | TRAF2, TRAF6 [cytosol]

TRAF2, TRAF6 [cytosol]

Stable Identifier

R-BTA-918188

Type

Set [DefinedSet]

Species

Bos taurus

Compartment

cytosol

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Cytokine Signaling in Immune system (Bos taurus)
  - Signaling by Interleukins (Bos taurus)
    - Interleukin-1 family signaling (Bos taurus)
      - Interleukin-1 signaling (Bos taurus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
        
        Regulation of NF-kappa B signaling (Bos taurus)
        
        TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
        
        TRAF2, TRAF6 [cytosol] (Bos taurus)
- Innate Immune System (Bos taurus)
  - Toll-like Receptor Cascades (Bos taurus)
    - Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
      - MyD88 cascade initiated on plasma membrane (Bos taurus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
        
        Regulation of NF-kappa B signaling (Bos taurus)
        
        TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
        
        TRAF2, TRAF6 [cytosol] (Bos taurus)
    - Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
        
        Regulation of NF-kappa B signaling (Bos taurus)
        
        TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
        
        TRAF2, TRAF6 [cytosol] (Bos taurus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
        
        Regulation of NF-kappa B signaling (Bos taurus)
        
        TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
        
        TRAF2, TRAF6 [cytosol] (Bos taurus)
    - Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
      - TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
        
        Regulation of NF-kappa B signaling (Bos taurus)
        
        TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
        
        TRAF2, TRAF6 [cytosol] (Bos taurus)
    - Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
      - MyD88-independent TLR4 cascade (Bos taurus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
        
        Regulation of NF-kappa B signaling (Bos taurus)
        
        TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
        
        TRAF2, TRAF6 [cytosol] (Bos taurus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
        
        Regulation of NF-kappa B signaling (Bos taurus)
        
        TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
        
        TRAF2, TRAF6 [cytosol] (Bos taurus)
    - Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
      - MyD88 cascade initiated on plasma membrane (Bos taurus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
        
        Regulation of NF-kappa B signaling (Bos taurus)
        
        TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
        
        TRAF2, TRAF6 [cytosol] (Bos taurus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
      - MyD88 dependent cascade initiated on endosome (Bos taurus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
        
        Regulation of NF-kappa B signaling (Bos taurus)
        
        TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
        
        TRAF2, TRAF6 [cytosol] (Bos taurus)
    - Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
      - MyD88 dependent cascade initiated on endosome (Bos taurus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
        
        Regulation of NF-kappa B signaling (Bos taurus)
        
        TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
        
        TRAF2, TRAF6 [cytosol] (Bos taurus)

Participants

members

Participates

as an output of

USP4 deubiquitinate TRAF2,TRAF6 (Bos taurus)

Inferred From

TRAF2, TRAF6 [cytosol] (Homo sapiens)