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About
What is Reactome ?
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Digital Preservation
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UBB [cytosol]
Stable Identifier
R-BTA-939248
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
Ub-63-RPS27A(1-76), P0CG53
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Regulation of T cell activation by CD28 family (Bos taurus)
Co-inhibition by PD-1 (Bos taurus)
Regulation of PD-L1(CD274) expression (Bos taurus)
Regulation of PD-L1(CD274) Post-translational modification (Bos taurus)
PD-L1(CD274) glycosylation and translocation to plasma membrane (Bos taurus)
MIB2-mediated K63-ubiquitination of CD274 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
Auto-ubiquitination of TRAF6 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Ubiquitination of NEMO by TRAF6 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
Pellino ubiquitinates IRAK1 (Bos taurus)
hp-IRAK1: p-Pellino-1,2,(3):UBE2N:UBE2V1:K63polyUb [cytosol] (Bos taurus)
UBE2N:UBE2V1:K63polyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Ubiquitination of IKBKG by TRAF6 (Bos taurus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
TRAF6 is K63 poly-ubiquitinated (Bos taurus)
hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] (Bos taurus)
UBE2N:UBE2V1:K63polyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Bos taurus)
UBE2N:UBE2V1:K63polyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] (Bos taurus)
UBE2N:UBE2V1:K63polyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Bos taurus)
IRAK1:Pellino:E2 complexes [cytosol] (Bos taurus)
IRAK4: p-Pellino-1,2,3:UBE2N:UBE2V1:K63polyUb [cytosol] (Bos taurus)
UBE2N:UBE2V1:K63polyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
hp-IRAK1: p-Pellino-1,2,(3):UBE2N:UBE2V1:K63polyUb [cytosol] (Bos taurus)
UBE2N:UBE2V1:K63polyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
UBE2N:UBE2V1:K63polyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Interleukin-17 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
TNFR2 non-canonical NF-kB pathway (Bos taurus)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
Alpha-protein kinase 1 signaling pathway (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
K63polyUb-TRAF6 ubiquitinates TAK1 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
TRAF6 oligomer autoubiquitinates (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Ubiquitination of NEMO by TRAF6 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated NF-kB activation (Bos taurus)
Auto-ubiquitination of TRAF6 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Ubiquitination of NEMO by TRAF6 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Bos taurus)
NOD1/2 Signaling Pathway (Bos taurus)
CYLD deubiquitinates NEMO (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
RIP2 induces K63-linked ubiquitination of NEMO (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
RIP2 is K63 polyubiquitinated (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
TNFAIP3 (A20) deubiquitinates RIP2 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
Pellino ubiquitinates hp-IRAK1 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Ubiquitination of IKBKG by TRAF6 (Bos taurus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
Pellino ubiquitinates hp-IRAK1 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Ubiquitination of IKBKG by TRAF6 (Bos taurus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
Pellino ubiquitinates hp-IRAK1 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Ubiquitination of IKBKG by TRAF6 (Bos taurus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Ubiquitination of IKBKG by TRAF6 (Bos taurus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
IKK complex recruitment mediated by RIP1 (Bos taurus)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Ubiquitination of IKBKG by TRAF6 (Bos taurus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Bos taurus)
Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Activation of TAK1 complex bound to activated TLR4 complex (Bos taurus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Phosphorylated TAK1 leaves activated TLR receptor complex (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
Pellino ubiquitinates hp-IRAK1 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Ubiquitination of IKBKG by TRAF6 (Bos taurus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
Pellino ubiquitinates hp-IRAK1 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Ubiquitination of IKBKG by TRAF6 (Bos taurus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Bos taurus)
Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
(Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Ubiquitination of IKBKG by TRAF6 (Bos taurus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Bos taurus)
Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
(Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Ubiquitination of IKBKG by TRAF6 (Bos taurus)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
Josephin domain DUBs (Bos taurus)
ATXN3 deubiquitinates polyUb-PARK2 (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
ATXN3 family cleave Ub chains (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
PARK2 autoubiquitinates (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Metalloprotease DUBs (Bos taurus)
BRISC complex deubiquitinates NLRP3 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
PSMD14 cleaves K63-linked ubiquitin (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
STAMBPL1 is a deubiquitinase (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Ovarian tumor domain proteases (Bos taurus)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
TNFAIP3 (A20) deubiquitinates RIP2 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Ub-specific processing proteases (Bos taurus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
USP11 deubiquitinates NFKBIA (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
USP13 deubiquitinates BECN1,USP10 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
USP18 deubiquitinates TAK1:TAB1 (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
USP19 deubiquitinates RNF123 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
USP20, USP33 deubiquitinate ADRB2 (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
USP21 deubiquitinates RIPK1,DDX58 (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
USP25 deubiquitinates DDX58 (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
USP33 deubiquitinates CCP110,ARRB (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
USP4 deubiquitinate TRAF2,TRAF6 (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
USP5 cleaves polyubiquitin (Bos taurus)
USP5:PolyUb [cytosol] (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
TNFR1-induced NF-kappa-B signaling pathway (Bos taurus)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS processing (Bos taurus)
USP17L2 deubiquitinates RCE1 (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
Transport of small molecules (Bos taurus)
Plasma lipoprotein assembly, remodeling, and clearance (Bos taurus)
Plasma lipoprotein clearance (Bos taurus)
VLDLR internalisation and degradation (Bos taurus)
MYLIP dimer ubiquitinates VLDLR on Lys-839 (Bos taurus)
K63-Ub [cytosol] (Bos taurus)
UBB [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:P0CG53
Gene Names
UBB
Reference Genes
BioGPS Gene:281370 UBIQ
ENSEMBL:ENSBTAG00000017246
KEGG:bta:281370 UBIQ
Monarch:281370 UBIQ
NCBI Gene:281370 UBIQ
UCSC:P0CG53 UBB
Reference Transcript
RefSeq:XM_059877708.1 UBIQ
RefSeq:XM_059877709.1 UBIQ
RefSeq:NM_174133.2 UBIQ
Other Identifiers
281370
Bt.2878.1.S1_at
Bt.2878.1.S1_x_at
GO:0005515
GO:0005739
GO:0007018
GO:0007141
GO:0007144
GO:0008584
GO:0008585
GO:0021888
GO:0022414
GO:0031398
GO:0043005
GO:0043025
GO:0043523
GO:0047497
GO:0048812
GO:0048856
GO:0051881
GO:0060612
GO:0060613
GO:0061136
GO:0072520
GO:0097009
GO:0140013
GO:1902255
GO:1902527
Participates
as a member of
K63-Ub [cytosol] (Bos taurus)
Other forms of this molecule
UBB [cytosol]
UBB [cytosol]
UBB [nucleoplasm]
UBB [nucleoplasm]
UBB [nucleoplasm]
UBB [nucleoplasm]
UBB [cytosol]
UBB [nucleoplasm]
UBB [nucleoplasm]
UBB [nucleoplasm]
UBB [nucleoplasm]
UBB [endoplasmic reticulum membrane]
UBB [cytosol]
UBB [cytosol]
UBB [cytosol]
UBB [cytosol]
UBB [cytosol]
UBB [mitochondrial outer membrane]
UBB [endosome membrane]
phospho-UBB [cytosol]
UBB [cytosol]
phospho-UBB [nucleoplasm]
UBB [cytosol]
UBB [mitochondrial outer membrane]
UBB [mitochondrial outer membrane]
UBB [mitochondrial outer membrane]
UBB [mitochondrial outer membrane]
UBB [mitochondrial outer membrane]
UBB [mitochondrial outer membrane]
UBB [nucleoplasm]
UBB [endocytic vesicle membrane]
Inferred From
Ub-63-RPS27A(1-76) [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine at 63 (in Homo sapiens)
Coordinate
63
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_059733691.1
,
NP_776558.1
,
XP_059733692.1
ENSEMBL
ENSBTAG00000017246
,
ENSBTAT00000094075
,
ENSBTAP00000099680
,
ENSBTAP00000022919
,
ENSBTAP00000102596
,
ENSBTAT00000022919
,
ENSBTAT00000102680
VGNC
107281
PDB
5TR4
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60784 TOM1
3
TOM1 [azurophil granule membrane]
(R-HSA-6799348)
TOM1 [plasma membrane]
(R-HSA-6806274)
TOM1 [specific granule membrane]
(R-HSA-6800923)
0.743
6
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