Reactome | LRRC7 [cytosol]

LRRC7 [cytosol]

Stable Identifier

R-BTA-9611351

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

LRRC7, A0A3Q1MGB1

Locations in the PathwayBrowser

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Neuronal System (Bos taurus)

- Transmission across Chemical Synapses (Bos taurus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Bos taurus)
    - Activation of NMDA receptors and postsynaptic events (Bos taurus)
      - Unblocking of NMDA receptors, glutamate binding and activation (Bos taurus)
        
        Ca2+ influx into the post-synaptic cell (Bos taurus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Bos taurus)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Bos taurus)
        
        LRRC7 [cytosol] (Bos taurus)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Bos taurus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Bos taurus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Bos taurus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Bos taurus)
        
        LRRC7 [cytosol] (Bos taurus)

Signal Transduction (Bos taurus)

- MAPK family signaling cascades (Bos taurus)
  - MAPK1/MAPK3 signaling (Bos taurus)
    - RAF/MAP kinase cascade (Bos taurus)
      - RAS GEFs promote RAS nucleotide exchange (Bos taurus)
        
        RAS GEFs [plasma membrane] (Bos taurus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Bos taurus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Bos taurus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Bos taurus)
        
        LRRC7 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:A0A3Q1MGB1

Gene Names

LRRC7

Reference Genes

ENSEMBL:ENSBTAG00000009338.6

Participates

as a component of

Other forms of this molecule

LRRC7 [extracellular region]

LRRC7 [specific granule lumen]

Inferred From

LRRC7 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000033122

VGNC

55251

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