Reactome | ASB9 [cytosol]

ASB9 [cytosol]

Stable Identifier

R-BTA-975424

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

ASB9, E1BKE5

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - Class I MHC mediated antigen processing & presentation (Bos taurus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
      - Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)
      - Polyubiquitination of substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)
      - Release of E3 from polyubiquitinated substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)
      - Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)

Metabolism of proteins (Bos taurus)

- Post-translational protein modification (Bos taurus)
  - Neddylation (Bos taurus)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Bos taurus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
        
        CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)
      - CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
        
        CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Bos taurus)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB9 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:E1BKE5

Gene Names

ASB9

Reference Genes

BioGPS Gene:784390 ASB9

ENSEMBL:ENSBTAG00000009198.6

KEGG Gene (Bos taurus):784390 ASB9

Monarch:784390 ASB9

NCBI Gene:784390 ASB9

Reference Transcript

Other Identifiers

784390

GO:0005515

GO:0016567

GO:0023052

GO:0030163

GO:0035556

GO:0036211

GO:0045732

Participates

as a member of

Inferred From

ASB9 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001178095.1, XP_005228514.1

OpenTargets

ENSG00000102048

Ensembl

ENSBTAP00000012118, ENSBTAP00000055026, ENSBTAT00000012118, ENSBTAG00000009198, ENSBTAT00000064207

VGNC

26202

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