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SMURF1 [cytosol]
Stable Identifier
R-BTA-975972
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
SMURF1, F1MLS5
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
Polyubiquitination of substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
Release of E3 from polyubiquitinated substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Hedgehog (Bos taurus)
Hedgehog 'on' state (Bos taurus)
SMURF1/2 dissociates from ub-PTCH1 (Bos taurus)
SMURF [cytosol] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
ub-PTCH1:SMURF [ciliary membrane] (Bos taurus)
SMURF [cytosol] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
Signaling by TGFB family members (Bos taurus)
Signaling by BMP (Bos taurus)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Bos taurus)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Bos taurus)
I-SMAD:SMURF [cytosol] (Bos taurus)
SMURF [cytosol] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
I-SMAD:SMURF [cytosol] (Bos taurus)
SMURF [cytosol] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Bos taurus)
SMURF [cytosol] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Bos taurus)
Disassembly of tight junctions (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
SMURF1 binds phosphorylated PARD6A (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
SMURF1 ubiquitinates RHOA (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
PCP/CE pathway (Bos taurus)
Asymmetric localization of PCP proteins (Bos taurus)
SMURF1/2 are recruited to the DVL2:PARD6A complex (Bos taurus)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Bos taurus)
SMURF [cytosol] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
SMURF [cytosol] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
SMURF1/2 ubiquitinates PRICKLE1 (Bos taurus)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Bos taurus)
SMURF [cytosol] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
SMURF [cytosol] (Bos taurus)
SMURF1 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:F1MLS5
Gene Names
SMURF1
Reference Genes
ENSEMBL:ENSBTAG00000007118.6
UCSC:F1MLS5 SMURF1
Other Identifiers
513902
GO:0000209
GO:0003824
GO:0004842
GO:0005160
GO:0005737
GO:0005739
GO:0005886
GO:0006511
GO:0006611
GO:0006886
GO:0006913
GO:0016740
GO:0030154
GO:0030163
GO:0030509
GO:0030512
GO:0030514
GO:0032801
GO:0032926
GO:0043161
GO:0043226
GO:0061024
GO:0061630
GO:0061736
GO:0061753
GO:0070411
GO:0070412
GO:0070697
GO:0071211
GO:0072659
GO:0140096
GO:1903861
GO:2000060
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
as an input of
SMURF1 binds phosphorylated PARD6A (Bos taurus)
as a component of
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Bos taurus)
as a member of
SMURF [cytosol] (Bos taurus)
Other forms of this molecule
SMURF1 [nucleoplasm]
Inferred From
SMURF1 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSBTAP00000041274
,
ENSBTAG00000007118
,
ENSBTAT00000043725
VGNC
35040
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