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GRB2-1:SOS1 [cytosol]
Stable Identifier
R-CEL-109797
Type
Complex
Species
Caenorhabditis elegans
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Caenorhabditis elegans)
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
RAS GEFs promote RAS nucleotide exchange (Caenorhabditis elegans)
RAS GEFs [plasma membrane] (Caenorhabditis elegans)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
GRB2:SOS1:p-KIT complex [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (q) signalling events (Caenorhabditis elegans)
Gastrin-CREB signalling pathway via PKC and MAPK (Caenorhabditis elegans)
EGFR Transactivation by Gastrin (Caenorhabditis elegans)
SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Caenorhabditis elegans)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by EGFR (Caenorhabditis elegans)
GRB2 events in EGFR signaling (Caenorhabditis elegans)
GRB2-1 binds SOS1 (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
GRB2:SOS1 complex binds to EGF:EGFR complex (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
SHC1 events in EGFR signaling (Caenorhabditis elegans)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Signaling by ERBB2 (Caenorhabditis elegans)
GRB2 events in ERBB2 signaling (Caenorhabditis elegans)
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Caenorhabditis elegans)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Signaling by FGFR (Caenorhabditis elegans)
Signaling by FGFR1 (Caenorhabditis elegans)
Downstream signaling of activated FGFR1 (Caenorhabditis elegans)
FRS-mediated FGFR1 signaling (Caenorhabditis elegans)
Activated FGFR1:p-FRS binds GRB2:SOS1 (Caenorhabditis elegans)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
SHC-mediated cascade:FGFR1 (Caenorhabditis elegans)
Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Caenorhabditis elegans)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Signaling by FGFR2 (Caenorhabditis elegans)
Downstream signaling of activated FGFR2 (Caenorhabditis elegans)
FRS-mediated FGFR2 signaling (Caenorhabditis elegans)
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
SHC-mediated cascade:FGFR2 (Caenorhabditis elegans)
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Signaling by FGFR3 (Caenorhabditis elegans)
Downstream signaling of activated FGFR3 (Caenorhabditis elegans)
FRS-mediated FGFR3 signaling (Caenorhabditis elegans)
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
SHC-mediated cascade:FGFR3 (Caenorhabditis elegans)
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Signaling by FGFR4 (Caenorhabditis elegans)
Downstream signaling of activated FGFR4 (Caenorhabditis elegans)
FRS-mediated FGFR4 signaling (Caenorhabditis elegans)
Activated FGFR4:p-FRS binds GRB2:SOS1 (Caenorhabditis elegans)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
SHC-mediated cascade:FGFR4 (Caenorhabditis elegans)
Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Caenorhabditis elegans)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Signaling by Insulin receptor (Caenorhabditis elegans)
Insulin receptor signalling cascade (Caenorhabditis elegans)
GRB2-1 binds SOS1 (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Signaling by MET (Caenorhabditis elegans)
MET activates RAS signaling (Caenorhabditis elegans)
Activated MET recruits GRB2-1:SOS1 (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Signaling by PDGF (Caenorhabditis elegans)
Downstream signal transduction (Caenorhabditis elegans)
GRB2:SOS1 complex binds to the active receptor (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Signaling by SCF-KIT (Caenorhabditis elegans)
Activation of RAS by p-KIT bound SOS1 (Caenorhabditis elegans)
GRB2:SOS1:p-KIT complex [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
Regulation of KIT signaling (Caenorhabditis elegans)
Recruitment of CBL to KIT (Caenorhabditis elegans)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Caenorhabditis elegans)
GRB2:SOS1:p-KIT complex [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
GRB2:SOS1:p-KIT complex [plasma membrane] (Caenorhabditis elegans)
GRB2-1:SOS1 [cytosol] (Caenorhabditis elegans)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
sem-5 [cytosol]
(Caenorhabditis elegans)
sos-1 [cytosol]
(Caenorhabditis elegans)
Participates
as an input of
Activated MET recruits GRB2-1:SOS1 (Caenorhabditis elegans)
Activated FGFR1:p-FRS binds GRB2:SOS1 (Caenorhabditis elegans)
Activated FGFR4:p-FRS binds GRB2:SOS1 (Caenorhabditis elegans)
GRB2:SOS1 complex binds to EGF:EGFR complex (Caenorhabditis elegans)
Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Caenorhabditis elegans)
GRB2:SOS1 complex binds to the active receptor (Caenorhabditis elegans)
Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Caenorhabditis elegans)
as an output of
GRB2-1 binds SOS1 (Caenorhabditis elegans)
as a component of
HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Caenorhabditis elegans)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Caenorhabditis elegans)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
GRB2:SOS1:p-KIT complex [plasma membrane] (Caenorhabditis elegans)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Caenorhabditis elegans)
Inferred From
GRB2-1:SOS1 [cytosol]
(Homo sapiens)
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