Reactome | set-16 [nucleoplasm]

set-16 [nucleoplasm]

Stable Identifier

R-CEL-1183219

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

KMT2D, G5EGI1

Locations in the PathwayBrowser

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Gene expression (Transcription) (Caenorhabditis elegans)

- Epigenetic regulation of gene expression (Caenorhabditis elegans)
  - Epigenetic regulation by WDR5-containing histone modifying complexes (Caenorhabditis elegans)
    - Formation of WDR5-containing histone-modifying complexes (Caenorhabditis elegans)
      - Formation of the MLL4 complex (Caenorhabditis elegans)
        
        MLL4 complex [nucleoplasm] (Caenorhabditis elegans)
        
        set-16 [nucleoplasm] (Caenorhabditis elegans)
        
        set-16 [nucleoplasm] (Caenorhabditis elegans)
- RNA Polymerase II Transcription (Caenorhabditis elegans)
  - Generic Transcription Pathway (Caenorhabditis elegans)
    - Transcriptional regulation by RUNX1 (Caenorhabditis elegans)
      - RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Caenorhabditis elegans)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Caenorhabditis elegans)
        
        Core MLL complex [nucleoplasm] (Caenorhabditis elegans)
        
        MLL4 complex [nucleoplasm] (Caenorhabditis elegans)
        
        set-16 [nucleoplasm] (Caenorhabditis elegans)
        
        H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Caenorhabditis elegans)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Caenorhabditis elegans)
        
        Core MLL complex [nucleoplasm] (Caenorhabditis elegans)
        
        MLL4 complex [nucleoplasm] (Caenorhabditis elegans)
        
        set-16 [nucleoplasm] (Caenorhabditis elegans)
        
        H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Caenorhabditis elegans)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Caenorhabditis elegans)
        
        Core MLL complex [nucleoplasm] (Caenorhabditis elegans)
        
        MLL4 complex [nucleoplasm] (Caenorhabditis elegans)
        
        set-16 [nucleoplasm] (Caenorhabditis elegans)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Caenorhabditis elegans)
        
        Core MLL complex [nucleoplasm] (Caenorhabditis elegans)
        
        MLL4 complex [nucleoplasm] (Caenorhabditis elegans)
        
        set-16 [nucleoplasm] (Caenorhabditis elegans)
        
        H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Caenorhabditis elegans)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Caenorhabditis elegans)
        
        Core MLL complex [nucleoplasm] (Caenorhabditis elegans)
        
        MLL4 complex [nucleoplasm] (Caenorhabditis elegans)
        
        set-16 [nucleoplasm] (Caenorhabditis elegans)
        
        H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Caenorhabditis elegans)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Caenorhabditis elegans)
        
        Core MLL complex [nucleoplasm] (Caenorhabditis elegans)
        
        MLL4 complex [nucleoplasm] (Caenorhabditis elegans)
        
        set-16 [nucleoplasm] (Caenorhabditis elegans)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Caenorhabditis elegans)
        
        H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Caenorhabditis elegans)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Caenorhabditis elegans)
        
        Core MLL complex [nucleoplasm] (Caenorhabditis elegans)
        
        MLL4 complex [nucleoplasm] (Caenorhabditis elegans)
        
        set-16 [nucleoplasm] (Caenorhabditis elegans)
        
        H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Caenorhabditis elegans)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Caenorhabditis elegans)
        
        Core MLL complex [nucleoplasm] (Caenorhabditis elegans)
        
        MLL4 complex [nucleoplasm] (Caenorhabditis elegans)
        
        set-16 [nucleoplasm] (Caenorhabditis elegans)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Caenorhabditis elegans)
        
        Core MLL complex [nucleoplasm] (Caenorhabditis elegans)
        
        MLL4 complex [nucleoplasm] (Caenorhabditis elegans)
        
        set-16 [nucleoplasm] (Caenorhabditis elegans)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Caenorhabditis elegans)
        
        Core MLL complex [nucleoplasm] (Caenorhabditis elegans)
        
        MLL4 complex [nucleoplasm] (Caenorhabditis elegans)
        
        set-16 [nucleoplasm] (Caenorhabditis elegans)
        
        H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Caenorhabditis elegans)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Caenorhabditis elegans)
        
        Core MLL complex [nucleoplasm] (Caenorhabditis elegans)
        
        MLL4 complex [nucleoplasm] (Caenorhabditis elegans)
        
        set-16 [nucleoplasm] (Caenorhabditis elegans)
        
        H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Caenorhabditis elegans)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Caenorhabditis elegans)
        
        Core MLL complex [nucleoplasm] (Caenorhabditis elegans)
        
        MLL4 complex [nucleoplasm] (Caenorhabditis elegans)
        
        set-16 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:G5EGI1

Gene Names

set-16

Reference Genes

BioGPS Gene:176802 set-16

ENSEMBL:WBGene00011729

KEGG Gene (Caenorhabditis elegans):CELE_T12D8.1 set-16

Monarch:176802 set-16

NCBI Gene:176802 set-16

Wormbase:WBGene00011729

Reference Transcript

RefSeq:NM_067418.4 set-16

Other Identifiers

176802

18515452

192544_s_at

A_12_P119727

A_12_P175402

CE16398

CE_WBGene00011729_A

CE_WBGene00011729_B

CE_WBGene00011729_C

CGZ0034831

GO:0005515

GO:0005634

GO:0043226

T12D8.1

T12D8.1_6735-6794_0.883_10_C

T12D8.1_7267-7326_0.886_9_B

T12D8.1_7450-7509_0.944_3_A

T12D8_1P06427

T12D8_1P06937

T12D8_1P07227

WBGene00011729

cea2.p.73336

Participates

as an input of

Formation of the MLL4 complex (Caenorhabditis elegans)

as a component of

Other forms of this molecule

set-16 [nucleoplasm]

Inferred From

KMT2D [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_499819.3

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