Reactome | ftt-2 [cytosol]

ftt-2 [cytosol]

Stable Identifier

R-CEL-1445116-2

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

YWHAQ, Q20655

Locations in the PathwayBrowser

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Cell Cycle (Caenorhabditis elegans)

- Cell Cycle Checkpoints (Caenorhabditis elegans)
  - G2/M Checkpoints (Caenorhabditis elegans)
    - G2/M DNA damage checkpoint (Caenorhabditis elegans)
      - Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Caenorhabditis elegans)
        
        Association of p-S216-CDC25C with 14-3-3 proteins (Caenorhabditis elegans)
        
        14-3-3 dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        ftt-2 [cytosol] (Caenorhabditis elegans)
        
        p-S216-CDC25C:14-3-3 protein complex [cytosol] (Caenorhabditis elegans)
        
        14-3-3 dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        ftt-2 [cytosol] (Caenorhabditis elegans)

Gene expression (Transcription) (Caenorhabditis elegans)

- RNA Polymerase II Transcription (Caenorhabditis elegans)
  - Generic Transcription Pathway (Caenorhabditis elegans)
    - FOXO-mediated transcription (Caenorhabditis elegans)
      - Regulation of localization of FOXO transcription factors (Caenorhabditis elegans)
        
        14-3-3 proteins bind AKT-phosphorylated FOXO1 (Caenorhabditis elegans)
        
        YWHAZ dimer,YWHAQ dimer,YWHAG dimer,YWHAB dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        ftt-2 [cytosol] (Caenorhabditis elegans)
        
        p-T24,S256,S319-FOXO1:YWHAZ,YWHAQ,YWHAG,YWHAB [cytosol] (Caenorhabditis elegans)
        
        YWHAZ dimer,YWHAQ dimer,YWHAG dimer,YWHAB dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        ftt-2 [cytosol] (Caenorhabditis elegans)
        
        14-3-3 proteins bind AKT-phosphorylated FOXO3 (Caenorhabditis elegans)
        
        YWHAZ dimer,YWHAQ dimer,SFN dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        ftt-2 [cytosol] (Caenorhabditis elegans)
        
        p-T32,S253,S315-FOXO3:YWHAZ,YWHAQ,SFN [cytosol] (Caenorhabditis elegans)
        
        YWHAZ dimer,YWHAQ dimer,SFN dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        ftt-2 [cytosol] (Caenorhabditis elegans)
        
        14-3-3 proteins bind AKT-phosphorylated FOXO4 (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        ftt-2 [cytosol] (Caenorhabditis elegans)
        
        p-T32,S197,S262-FOXO4:YWHAZ dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        ftt-2 [cytosol] (Caenorhabditis elegans)

Hemostasis (Caenorhabditis elegans)

- Platelet activation, signaling and aggregation (Caenorhabditis elegans)
  - GP1b-IX-V activation signalling (Caenorhabditis elegans)
    - 14-3-3-zeta binds Raf1 (Caenorhabditis elegans)
      - 14-3-3-zeta:Raf1 [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        ftt-2 [cytosol] (Caenorhabditis elegans)
      - YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        ftt-2 [cytosol] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by NOTCH (Caenorhabditis elegans)
  - Signaling by NOTCH4 (Caenorhabditis elegans)
    - NOTCH4 Activation and Transmission of Signal to the Nucleus (Caenorhabditis elegans)
      - NICD4 traffics to the nucleus (Caenorhabditis elegans)
        
        p-4S-NICD4:YWHAZ dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        ftt-2 [cytosol] (Caenorhabditis elegans)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
  - Signaling by Rho GTPases (Caenorhabditis elegans)
    - RHO GTPase Effectors (Caenorhabditis elegans)
      - RHO GTPases activate PKNs (Caenorhabditis elegans)
        
        Association of p-S216-CDC25C with 14-3-3 proteins (Caenorhabditis elegans)
        
        14-3-3 dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        ftt-2 [cytosol] (Caenorhabditis elegans)
        
        p-S216-CDC25C:14-3-3 protein complex [cytosol] (Caenorhabditis elegans)
        
        14-3-3 dimer [cytosol] (Caenorhabditis elegans)
        
        YWHAQ dimer [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        ftt-2 [cytosol] (Caenorhabditis elegans)
- Signaling by WNT (Caenorhabditis elegans)
  - TCF dependent signaling in response to WNT (Caenorhabditis elegans)
    - Deactivation of the beta-catenin transactivating complex (Caenorhabditis elegans)
      - YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Caenorhabditis elegans)
        
        XPO1:YWHAZ:p-S20-CBY1:CTNNB1 [cytosol] (Caenorhabditis elegans)
        
        Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)
        
        ftt-2 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q20655

Gene Names

ftt-2

Reference Genes

BioGPS Gene:181348 ftt-2

ENSEMBL:WBGene00001502

Monarch:181348 ftt-2

NCBI Gene:181348 ftt-2

UCSC:Q20655 ftt-2

Wormbase:WBGene00001502

Reference Transcript

RefSeq:NM_077538.4 ftt-2

Other Identifiers

171773_x_at

171955_x_at

181348

18626986

187954_s_at

A_12_P103085

A_12_P118863

A_12_P143255

CE03389

CE28235

CE_WBGene00001502_A

CGZ0023099

CGZ0023101

F52D10.3

F52D10.3a

F52D10.3a_231-290_0.928_3_B

F52D10.3a_315-374_0.722_30_C

F52D10.3a_453-512_0.941_1_A

F52D10.3b

F52D10_3aP00586

F52D10_3aP00656

F52D10_3aP00676

F52D10_3bP00038

F52D10_3bP00387

GO:0005515

GO:0005634

GO:0005737

GO:0007165

GO:0008104

GO:0010468

GO:0010629

GO:0040024

GO:0042308

GO:0043226

GO:0048856

GO:0051220

GO:0051457

GO:0140297

WBGene00001502

cea2.c.45558

cea2.d.03729

Participates

as a member of

Homologues of YWHAQ [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

ftt-2 [nucleoplasm]

ftt-2 [cytosol]

Inferred From

YWHAZ [cytosol] (Homo sapiens)

YWHAQ [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_509939.1

ENSEMBL

F52D10.3a.1

PRO

Q20655

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q21921	1	SIRT1 [nucleoplasm] (R-CEL-427531)	0.632	3
UniProt:Q11184	2	let-756 [extracellular region] (R-CEL-189898) let-756 [extracellular region] (R-CEL-189856)	0.543	3
UniProt:G5EC23	2	hcf-1 [nucleoplasm] (R-CEL-9821232) hcf-1 [nucleoplasm] (R-CEL-1592209)	0.499	2

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