Reactome | pab-1 [cytosol]

pab-1 [cytosol]

Stable Identifier

R-CEL-156803

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

PABPC1, Q9U302

Locations in the PathwayBrowser

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Metabolism of RNA (Caenorhabditis elegans)

- Nonsense-Mediated Decay (NMD) (Caenorhabditis elegans)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Caenorhabditis elegans)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Caenorhabditis elegans)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Caenorhabditis elegans)
        
        pab-1 [cytosol] (Caenorhabditis elegans)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Caenorhabditis elegans)
        
        pab-1 [cytosol] (Caenorhabditis elegans)
    - SMG6 hydrolyzes mRNA with premature termination codon (Caenorhabditis elegans)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Caenorhabditis elegans)
        
        pab-1 [cytosol] (Caenorhabditis elegans)
      - mRNA Cleaved by SMG6 [cytosol] (Caenorhabditis elegans)
        
        pab-1 [cytosol] (Caenorhabditis elegans)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Caenorhabditis elegans)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Caenorhabditis elegans)
        
        pab-1 [cytosol] (Caenorhabditis elegans)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Caenorhabditis elegans)
        
        pab-1 [cytosol] (Caenorhabditis elegans)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Caenorhabditis elegans)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Caenorhabditis elegans)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Caenorhabditis elegans)
        
        pab-1 [cytosol] (Caenorhabditis elegans)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Caenorhabditis elegans)
        
        pab-1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9U302

Gene Names

pab-1

Reference Genes

ENSEMBL:WBGene00003902

UCSC:Q9U302 pab-1

Wormbase:WBGene00003902

Reference Transcript

RefSeq:NM_001026538.4 pab-1

Other Identifiers

172007_x_at

172920

174670_s_at

18474887

194118_s_at

A_12_P101629

A_12_P146565

A_12_P146566

A_12_P166559

A_12_P166560

A_12_P166561

A_12_P166562

A_12_P166563

CE20412

CE_WBGene00003902_A

CE_WBGene00003902_C

CGZ0042001

CGZ0042005

GO:0003676

GO:0003723

WBGene00003902

Y106G6H.2

Y106G6H.2a_1169-1228_0.890_49_B

Y106G6H.2a_1802-1861_0.942_11_A

Y106G6H.2a_933-992_0.893_47_C

Y106G6H_2aP01002

Y106G6H_2aP01344

Y106G6H_2aP01863

Y106G6H_2cP00309

cea2.c.08399

Participates

as a component of

as an input of

Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Caenorhabditis elegans)

Inferred From

PABPC1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001021709.1

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