Reactome | PPP2CA [cytosol]

PPP2CA [cytosol]

Stable Identifier

R-CEL-165971

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

G5EGK8

Locations in the PathwayBrowser

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Immune System (Caenorhabditis elegans)

- Adaptive Immune System (Caenorhabditis elegans)
  - Costimulation by the CD28 family (Caenorhabditis elegans)
    - CTLA4 inhibitory signaling (Caenorhabditis elegans)
      - Dephosphorylation of AKT by PP2A (Caenorhabditis elegans)
        
        PP2A [cytosol] (Caenorhabditis elegans)
        
        PP2A-catalytic subunit C [cytosol] (Caenorhabditis elegans)
        
        PPP2CA [cytosol] (Caenorhabditis elegans)
- Cytokine Signaling in Immune system (Caenorhabditis elegans)
  - Interferon Signaling (Caenorhabditis elegans)
    - Antiviral mechanism by IFN-stimulated genes (Caenorhabditis elegans)
      - PKR-mediated signaling (Caenorhabditis elegans)
        
        p-PKR dimer phosphorylates PPP2R5A (Caenorhabditis elegans)
        
        Activated PPP2R5A-specific PP2A [cytosol] (Caenorhabditis elegans)
        
        PP2A-catalytic subunit C [cytosol] (Caenorhabditis elegans)
        
        PPP2CA [cytosol] (Caenorhabditis elegans)
        
        PPP2R5A-specific PP2A [cytosol] (Caenorhabditis elegans)
        
        PP2A-catalytic subunit C [cytosol] (Caenorhabditis elegans)
        
        PPP2CA [cytosol] (Caenorhabditis elegans)

Metabolism of RNA (Caenorhabditis elegans)

- Nonsense-Mediated Decay (NMD) (Caenorhabditis elegans)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Caenorhabditis elegans)
    - SMG6 hydrolyzes mRNA with premature termination codon (Caenorhabditis elegans)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Caenorhabditis elegans)
        
        PPP2CA [cytosol] (Caenorhabditis elegans)
      - mRNA Cleaved by SMG6 [cytosol] (Caenorhabditis elegans)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Caenorhabditis elegans)
        
        PPP2CA [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:G5EGK8

Reference Genes

ENSEMBL:WBGene00002363

Wormbase:WBGene00002363

Reference Transcript

RefSeq:NM_069846.3

Other Identifiers

174899_at

178117

18538105

18538136

192750_at

A_12_P119836

A_12_P142875

A_12_P142876

A_12_P142877

A_12_P142878

A_12_P142879

CE10074

CE_WBGene00002363_A

CE_WBGene00002363_B

CGZ0020604

F38H4.9

F38H4.9_136-195_0.890_8_C

F38H4.9_421-480_0.889_9_A

F38H4.9_48-107_0.901_4_B

F38H4_10P00022

F38H4_10P00184

F38H4_9P00004

F38H4_9P00653

F38H4_9P00877

GO:0003824

GO:0004722

GO:0016787

GO:0140096

WBGene00002363

cea2.c.28643

Participates

as a component of

as a candidate of

PP2A-catalytic subunit C [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

MeL-PPP2CA [nucleoplasm]

phospho-p-Y307-PPP2CA [cytosol]

PPP2CA [nucleoplasm]

Inferred From

PP2A (Calpha/Cbeta) [cytosol] (Homo sapiens)

PPP2CB [cytosol] (Homo sapiens)

PPP2CA [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_502247.1

IntEnz

3.1.3.16

PRO

G5EGK8

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