Reactome | BRK1 [cytosol]

BRK1 [cytosol]

Stable Identifier

R-CEL-1671645

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

A5Z2X2

Locations in the PathwayBrowser

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Immune System (Caenorhabditis elegans)

- Innate Immune System (Caenorhabditis elegans)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Caenorhabditis elegans)
    - Regulation of actin dynamics for phagocytic cup formation (Caenorhabditis elegans)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
        
        Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
        
        p-Y,S,T-WRC [cytosol] (Caenorhabditis elegans)
        
        BRK1 [cytosol] (Caenorhabditis elegans)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y-WRC [cytosol] (Caenorhabditis elegans)
        
        BRK1 [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
        
        p-Y,S,T-WRC [cytosol] (Caenorhabditis elegans)
        
        BRK1 [cytosol] (Caenorhabditis elegans)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y-WRC [cytosol] (Caenorhabditis elegans)
        
        BRK1 [cytosol] (Caenorhabditis elegans)
      - ABL phosphorylates WAVEs (Caenorhabditis elegans)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        WAVE Regulatory Complex [cytosol] (Caenorhabditis elegans)
        
        BRK1 [cytosol] (Caenorhabditis elegans)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y-WRC [cytosol] (Caenorhabditis elegans)
        
        BRK1 [cytosol] (Caenorhabditis elegans)
      - Detachment of WASP/WAVE (Caenorhabditis elegans)
        
        Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
        
        p-Y,S,T-WRC [cytosol] (Caenorhabditis elegans)
        
        BRK1 [cytosol] (Caenorhabditis elegans)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y-WRC [cytosol] (Caenorhabditis elegans)
        
        BRK1 [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
        
        p-Y,S,T-WRC [cytosol] (Caenorhabditis elegans)
        
        BRK1 [cytosol] (Caenorhabditis elegans)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y-WRC [cytosol] (Caenorhabditis elegans)
        
        BRK1 [cytosol] (Caenorhabditis elegans)
      - p-ERK phosphorylates WAVEs and ABI (Caenorhabditis elegans)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
        
        p-Y,S,T-WRC [cytosol] (Caenorhabditis elegans)
        
        BRK1 [cytosol] (Caenorhabditis elegans)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y-WRC [cytosol] (Caenorhabditis elegans)
        
        BRK1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:A5Z2X2

Reference Genes

ENSEMBL:WBGene00303007

UCSC:A5Z2X2

Wormbase:WBGene00303007

Reference Transcript

RefSeq:NM_001129349.2

Other Identifiers

175136_at

178404

18559267

192257_s_at

A_12_P104820

A_12_P144630

A_12_P144631

A_12_P144632

A_12_P152695

A_12_P152696

A_12_P152697

A_12_P152698

A_12_P152699

CE14946

CE14948

CE_WBGene00013308_A

CE_WBGene00013308_C

CGZ0050206

CGZ0050210

GO:0005737

GO:0005856

GO:0007010

GO:0007015

GO:0008064

GO:0031209

GO:0043226

GO:0044877

GO:0048870

Y57G11C.11a_199-258_0.922_4_C

Y57G11C.12

Y57G11C.12b_195-254_0.914_5_B

Y57G11C.12b_324-383_0.964_1_A

Y57G11C.12b_62-121_0.812_20_C

Y57G11C_11aP00122

Y57G11C_12P00004

Y57G11C_12P00137

Y57G11C_12P00278

cea2.c.32237

Participates

as a candidate of

as a component of

Inferred From

BRK1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001122821.1

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