Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
sma-4 [nucleoplasm]
Stable Identifier
R-CEL-177103
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
nucleoplasm
Synonyms
SMAD4, P45897
Locations in the PathwayBrowser
Expand all
Developmental Biology (Caenorhabditis elegans)
Signaling by NODAL (Caenorhabditis elegans)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Caenorhabditis elegans)
SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
FOXO-mediated transcription (Caenorhabditis elegans)
FOXO-mediated transcription of cell cycle genes (Caenorhabditis elegans)
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Caenorhabditis elegans)
FOXO1,FOXO3,FOXO4:p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Caenorhabditis elegans)
Degradation of SMAD2/3:SMAD4 complex (Caenorhabditis elegans)
Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
NEDD4L binds phosphorylated linker region of SMAD2/3 (Caenorhabditis elegans)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
NEDD4L ubiquitinates SMAD2/3 (Caenorhabditis elegans)
Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
PPM1A dephosphorylates nuclear SMAD2/3 (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Caenorhabditis elegans)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
WWTR1:SMAD translocates to the nucleus (Caenorhabditis elegans)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
Transcriptional regulation by RUNX2 (Caenorhabditis elegans)
RUNX2 regulates bone development (Caenorhabditis elegans)
RUNX2 binds SMAD1 in the nucleus (Caenorhabditis elegans)
RUNX2:CBFB:p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
Transcriptional regulation by RUNX3 (Caenorhabditis elegans)
RUNX3 regulates CDKN1A transcription (Caenorhabditis elegans)
RUNX3 binds SMAD3 and SMAD4 (Caenorhabditis elegans)
RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
Signaling by TGFB family members (Caenorhabditis elegans)
Signaling by Activin (Caenorhabditis elegans)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
Signaling by BMP (Caenorhabditis elegans)
The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Caenorhabditis elegans)
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Caenorhabditis elegans)
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
Signaling by TGF-beta Receptor Complex (Caenorhabditis elegans)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Caenorhabditis elegans)
Degradation of SMAD2/3:SMAD4 complex (Caenorhabditis elegans)
Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
NEDD4L binds phosphorylated linker region of SMAD2/3 (Caenorhabditis elegans)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
NEDD4L ubiquitinates SMAD2/3 (Caenorhabditis elegans)
Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
PPM1A dephosphorylates nuclear SMAD2/3 (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Caenorhabditis elegans)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
WWTR1:SMAD translocates to the nucleus (Caenorhabditis elegans)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
sma-4 [nucleoplasm] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:P45897
Gene Names
sma-4
Reference Genes
BioGPS Gene:175815 sma-4
CTD Gene:175815 sma-4
ENSEMBL:WBGene00004858
KEGG:cel:CELE_R12B2.1 sma-4
Monarch:175815 sma-4
NCBI Gene:175815 sma-4
UCSC:P45897 sma-4
Wormbase:WBGene00004858
Wormbase:WBGene00004858 sma-4
Reference Transcript
RefSeq:NM_001047399.2 sma-4
Participates
as a component of
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
as an output of
PPM1A dephosphorylates nuclear SMAD2/3 (Caenorhabditis elegans)
Other forms of this molecule
phospho-sma-4 [nucleoplasm]
sma-4 [nucleoplasm]
sma-4 [cytosol]
sma-4 [cytosol]
Inferred From
SMAD4 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001040864.1
PRO
P45897
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text