Reactome | elb-1 [cytosol]

elb-1 [cytosol]

Stable Identifier

R-CEL-180551

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

ELOB, G5ECR7

Locations in the PathwayBrowser

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Cellular responses to stimuli (Caenorhabditis elegans)

- Cellular responses to stress (Caenorhabditis elegans)
  - Cellular response to hypoxia (Caenorhabditis elegans)
    - Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Caenorhabditis elegans)
      - Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        elb-1 [cytosol] (Caenorhabditis elegans)
      - Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        elb-1 [cytosol] (Caenorhabditis elegans)
      - Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)
        
        hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Caenorhabditis elegans)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        elb-1 [cytosol] (Caenorhabditis elegans)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Caenorhabditis elegans)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        elb-1 [cytosol] (Caenorhabditis elegans)
      - Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        elb-1 [cytosol] (Caenorhabditis elegans)
        
        hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Caenorhabditis elegans)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        elb-1 [cytosol] (Caenorhabditis elegans)
      - Proteasome proteolyzes ub-HIF-alpha (Caenorhabditis elegans)
        
        VBC complex (with or without LIMD1) [cytosol] (Caenorhabditis elegans)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        elb-1 [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        elb-1 [cytosol] (Caenorhabditis elegans)
        
        ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Caenorhabditis elegans)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        elb-1 [cytosol] (Caenorhabditis elegans)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Caenorhabditis elegans)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        elb-1 [cytosol] (Caenorhabditis elegans)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Caenorhabditis elegans)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
        
        VBC complex [cytosol] (Caenorhabditis elegans)
        
        elb-1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:G5ECR7

Gene Names

elb-1

Reference Genes

BioGPS Gene:176605 elb-1

ENSEMBL:WBGene00001235

Monarch:176605 elb-1

NCBI Gene:176605 elb-1

Wormbase:WBGene00001235

Reference Transcript

RefSeq:NM_067116.6 elb-1

Other Identifiers

173581_s_at

176605

18529349

A_12_P117857

CE20250

CE_WBGene00001235_A

CE_WBGene00001235_C

CGZ0045439

GO:0005634

GO:0005654

GO:0006351

GO:0006368

GO:0030891

GO:0043226

GO:0070449

WBGene00001235

Y41C4A.10

Y41C4A.10_124-183_0.949_1_A

Y41C4A.10_304-363_0.712_10_C

Y41C4A.10_35-94_0.717_9_B

Y41C4A_10P00008

Y41C4A_10P00213

Y41C4A_10P00229

cea2.c.24011

Participates

as a component of

Other forms of this molecule

elb-1 [nucleoplasm]

Inferred From

ELOB [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_499517.1

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BKS1	2	elc-1 [nucleoplasm] (R-CEL-112422) elc-1 [cytosol] (R-CEL-180535)	0.553	3

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