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unc-57 [cytosol]
Stable Identifier
R-CEL-182958
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
cytosol
Synonyms
SH3GL2, B1V8A0
Locations in the PathwayBrowser
Expand all
Signal Transduction (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by EGFR (Caenorhabditis elegans)
EGFR downregulation (Caenorhabditis elegans)
Assembly of EGFR complex in clathrin-coated vesicles (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
CBL-mediated ubiquitination of CIN85 (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Caenorhabditis elegans)
Ub-CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGFR binds EPS15, EPN1, EPS15L1 (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGFR non-clathrin mediated endocytosis (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGFR phosphorylates EPS15 (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
PTPN3 dephosphorylates EPS15 (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
Signaling by MET (Caenorhabditis elegans)
Negative regulation of MET activity (Caenorhabditis elegans)
CBL recruits CIN85:endophilin to ubiquitinated MET (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EPS15 and HGS bind ubiquitinated MET (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
Vesicle-mediated transport (Caenorhabditis elegans)
Membrane Trafficking (Caenorhabditis elegans)
Clathrin-mediated endocytosis (Caenorhabditis elegans)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
BAR domain proteins recruit dynamin (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
Cargo recognition for clathrin-mediated endocytosis (Caenorhabditis elegans)
Epsin family proteins bind ubiquitinated cargo (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
trans-Golgi Network Vesicle Budding (Caenorhabditis elegans)
Golgi Associated Vesicle Biogenesis (Caenorhabditis elegans)
trans-Golgi Network Coat Assembly (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
trans-Golgi Network Vesicle Scission (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
Lysosome Vesicle Biogenesis (Caenorhabditis elegans)
trans-Golgi Network Lysosomal Vesicle Scission (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:B1V8A0
Gene Names
unc-57
Reference Genes
BioGPS Gene:172078 unc-57
CTD Gene:172078 unc-57
ENSEMBL:WBGene00006791
KEGG Gene (Caenorhabditis elegans):CELE_T04D1.3 unc-57
Monarch:172078 unc-57
NCBI Gene:172078 unc-57
UCSC:B1V8A0 unc-57
Wormbase:WBGene00006791
Reference Transcript
RefSeq:NM_001129040.2 unc-57
RefSeq:NM_001047216.1 unc-57
RefSeq:NM_001129041.2 unc-57
RefSeq:NM_001047215.3 unc-57
Other Identifiers
172078
181212_at
18458874
A_12_P117099
A_12_P153830
CE18195
CE_WBGene00006791_A
CE_WBGene00006791_B
CE_WBGene00006791_C
CGZ0033148
CGZ0033151
GO:0005515
GO:0005737
T04D1.3
T04D1.3d_1042-1101_0.955_1_A
T04D1.3d_734-793_0.940_5_C
T04D1.3d_961-1020_0.932_7_B
T04D1_3aP00024
T04D1_3aP00309
T04D1_3aP00596
T04D1_3bP00001
T04D1_3bP00069
T04D1_3bP00195
WBGene00006791
cea2.p.16165
Participates
as an output of
trans-Golgi Network Vesicle Scission (Caenorhabditis elegans)
trans-Golgi Network Lysosomal Vesicle Scission (Caenorhabditis elegans)
as an input of
trans-Golgi Network Coat Assembly (Caenorhabditis elegans)
trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Caenorhabditis elegans)
as a component of
SH3GL2 dimer [cytosol] (Caenorhabditis elegans)
Other forms of this molecule
unc-57 [Golgi membrane]
unc-57 [plasma membrane]
unc-57 [cytosol]
unc-57 [cytosol]
Inferred From
SH3GL2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001040680.1
,
NP_001122512.1
,
NP_001040681.1
,
NP_001122513.1
PRO
B1V8A0
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