Reactome | mec-7 [cytosol]

mec-7 [cytosol]

Stable Identifier

R-CEL-190588-3

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

TUBB4A, P12456

Locations in the PathwayBrowser

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Autophagy (Caenorhabditis elegans)

- Macroautophagy (Caenorhabditis elegans)
  - Selective autophagy (Caenorhabditis elegans)
    - Aggrephagy (Caenorhabditis elegans)
      - Aggresome dissociates from dynein and microtubule (Caenorhabditis elegans)
        
        Microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Caenorhabditis elegans)
        
        PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Caenorhabditis elegans)
        
        Microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)

Cell Cycle (Caenorhabditis elegans)

- Cell Cycle, Mitotic (Caenorhabditis elegans)
  - M Phase (Caenorhabditis elegans)
    - Mitotic Metaphase and Anaphase (Caenorhabditis elegans)
      - Mitotic Anaphase (Caenorhabditis elegans)
        
        Nuclear Envelope (NE) Reassembly (Caenorhabditis elegans)
        
        Sealing of the nuclear envelope (NE) by ESCRT-III (Caenorhabditis elegans)
        
        SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Caenorhabditis elegans)
        
        Microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)

Hemostasis (Caenorhabditis elegans)

- Factors involved in megakaryocyte development and platelet production (Caenorhabditis elegans)
  - Kinesins (Caenorhabditis elegans)
    - Kinesins bind microtubules (Caenorhabditis elegans)
      - Kinesins:microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)
      - Microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)
    - Kinesins move along microtubules consuming ATP (Caenorhabditis elegans)
      - Kinesins:microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)

Metabolism of proteins (Caenorhabditis elegans)

- Post-translational protein modification (Caenorhabditis elegans)
  - Asparagine N-linked glycosylation (Caenorhabditis elegans)
    - Transport to the Golgi and subsequent modification (Caenorhabditis elegans)
      - ER to Golgi Anterograde Transport (Caenorhabditis elegans)
        
        COPI-mediated anterograde transport (Caenorhabditis elegans)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Caenorhabditis elegans)
        
        Dynein:Dynactin:microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Caenorhabditis elegans)
        
        Dynein:Dynactin:microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)
  - Carboxyterminal post-translational modifications of tubulin (Caenorhabditis elegans)
    - TTLLs polyglutamylate tubulin (Caenorhabditis elegans)
      - Microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)
      - Polyglutamylated microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)

Organelle biogenesis and maintenance (Caenorhabditis elegans)

- Cilium Assembly (Caenorhabditis elegans)
  - ATAT acetylates microtubules (Caenorhabditis elegans)
    - Microtubule [cytosol] (Caenorhabditis elegans)
      - Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)
    - acetylated microtubule [cytosol] (Caenorhabditis elegans)
      - acetylated microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        Ac K40 alpha tubulin-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)
  - HDAC6 deacetylates microtubules (Caenorhabditis elegans)
    - Microtubule [cytosol] (Caenorhabditis elegans)
      - Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)
    - acetylated microtubule [cytosol] (Caenorhabditis elegans)
      - acetylated microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        Ac K40 alpha tubulin-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)

Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - ER to Golgi Anterograde Transport (Caenorhabditis elegans)
    - COPI-mediated anterograde transport (Caenorhabditis elegans)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Caenorhabditis elegans)
        
        Dynein:Dynactin:microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Caenorhabditis elegans)
        
        Dynein:Dynactin:microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Caenorhabditis elegans)
    - Golgi-to-ER retrograde transport (Caenorhabditis elegans)
      - COPI-dependent Golgi-to-ER retrograde traffic (Caenorhabditis elegans)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Caenorhabditis elegans)
        
        Kinesins:microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Caenorhabditis elegans)
        
        Kinesins:microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)
      - COPI-independent Golgi-to-ER retrograde traffic (Caenorhabditis elegans)
        
        Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Caenorhabditis elegans)
        
        Dynein:Dynactin:microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Caenorhabditis elegans)
        
        Dynein:Dynactin:microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)
        
        RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Caenorhabditis elegans)
        
        Dynein:Dynactin:microtubules:PAFAH1B1 [cytosol] (Caenorhabditis elegans)
        
        Dynein:Dynactin:microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Caenorhabditis elegans)
        
        Dynein:Dynactin:microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule [cytosol] (Caenorhabditis elegans)
        
        Microtubule protofilament [cytosol] (Caenorhabditis elegans)
        
        alpha-beta tubulin dimer [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin:GDP [cytosol] (Caenorhabditis elegans)
        
        beta-tubulin [cytosol] (Caenorhabditis elegans)
        
        Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)
        
        mec-7 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:P12456

Gene Names

mec-7

Reference Genes

BioGPS Gene:181036 mec-7

ENSEMBL:WBGene00003171

KEGG Gene (Caenorhabditis elegans):CELE_ZK154.3 mec-7

Monarch:181036 mec-7

NCBI Gene:181036 mec-7

UCSC:P12456 mec-7

Wormbase:WBGene00003171

Reference Transcript

RefSeq:NM_076912.3 mec-7

Other Identifiers

171793_x_at

181036

18633928

191320_s_at

A_12_P115480

CE15257

CE_WBGene00003171_A

CGZ0056460

GO:0000166

GO:0000226

GO:0000278

GO:0003674

GO:0003924

GO:0005198

GO:0005200

GO:0005525

GO:0005575

GO:0005622

GO:0005737

GO:0005856

GO:0005874

GO:0007010

GO:0007017

GO:0007049

GO:0007638

GO:0008150

GO:0009612

GO:0031122

GO:0043005

GO:0043025

GO:0043167

GO:0043226

GO:0050877

GO:0050974

GO:0050976

GO:1905789

GO:1905792

WBGene00003171

ZK154.3

ZK154.3_1053-1112_0.929_19_A

ZK154_3P00070

ZK154_3P00802

ZK154_3P00820

cea2.3.31320

cea2.p.157343

Participates

as a member of

Homologues of TUBB4A [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

mec-7 [cytosol]

mec-7 [axonemal microtubule]

mec-7 [azurophil granule lumen]

mec-7 [extracellular region]

mec-7 [cytosol]

Inferred From

Tubulin beta-8 chain-like protein [cytosol] (Homo sapiens)

TUBB4A [cytosol] (Homo sapiens)

TUBB8 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_509313.1

PRO

P12456

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