Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
RHOA [plasma membrane]
Stable Identifier
R-CEL-194510
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
plasma membrane
Synonyms
Q22038
Locations in the PathwayBrowser
Expand all
Developmental Biology (Caenorhabditis elegans)
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
EPH-Ephrin signaling (Caenorhabditis elegans)
EPHA-mediated growth cone collapse (Caenorhabditis elegans)
NGEF exchanges GTP for GDP on RHOA (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
EPHB-mediated forward signaling (Caenorhabditis elegans)
RHOA:GTP binds ROCK, activating it (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Semaphorin interactions (Caenorhabditis elegans)
Sema4D in semaphorin signaling (Caenorhabditis elegans)
Sema4D induced cell migration and growth-cone collapse (Caenorhabditis elegans)
Activation of Rho by LARG and PDZ-RhoGEF (Caenorhabditis elegans)
RHOA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RhoA,B,C:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
ROCK activation by RHO (Caenorhabditis elegans)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Sema4D mediated inhibition of cell attachment and migration (Caenorhabditis elegans)
Inactivation of Rho-GTP by p190RhoGAP (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Signaling by ROBO receptors (Caenorhabditis elegans)
SLIT2:ROBO1 increases RHOA activity (Caenorhabditis elegans)
MYO9B inactivates RHOA (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Immune System (Caenorhabditis elegans)
Innate Immune System (Caenorhabditis elegans)
Neutrophil degranulation (Caenorhabditis elegans)
Exocytosis of ficolin-rich granule membrane proteins (Caenorhabditis elegans)
Ficolin-rich granule membrane proteins [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Exocytosis of secretory granule membrane proteins (Caenorhabditis elegans)
Secretory granule membrane proteins [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
Death Receptor Signaling (Caenorhabditis elegans)
p75 NTR receptor-mediated signalling (Caenorhabditis elegans)
p75NTR regulates axonogenesis (Caenorhabditis elegans)
Axonal growth inhibition (RHOA activation) (Caenorhabditis elegans)
RhoA is activated by nucleotide exchange and inhibits axonal growth (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (12/13) signalling events (Caenorhabditis elegans)
GEFs activate RhoA,B,C (Caenorhabditis elegans)
RHOA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RhoA,B,C:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
ROCK activation by RHO (Caenorhabditis elegans)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
p115-RhoGEF activation of RHOA (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
G-protein beta:gamma signalling (Caenorhabditis elegans)
G beta:gamma signalling through PI3Kgamma (Caenorhabditis elegans)
PIP3 binds to RhoA and activates it (Caenorhabditis elegans)
PIP3:RhoA [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Signaling by Non-Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by PTK6 (Caenorhabditis elegans)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Caenorhabditis elegans)
ARHGAP35 binds RHOA:GTP (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
p-Y1105-ARHGAP35:RHOA:GTP [cytosol] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
ARHGAP35 stimulates RHOA GTPase activity (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
p-Y1105-ARHGAP35:RHOA:GTP [cytosol] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by ERBB2 (Caenorhabditis elegans)
ERBB2 Regulates Cell Motility (Caenorhabditis elegans)
MEMO1 binds RHOA:GTP:DIAPH1 (Caenorhabditis elegans)
RHOA:GTP:DIAPH1 [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1 [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP:DIAPH1 [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Signaling by NTRKs (Caenorhabditis elegans)
Signaling by NTRK1 (TRKA) (Caenorhabditis elegans)
PI3K/AKT activation (Caenorhabditis elegans)
PIP3 binds to RhoA and activates it (Caenorhabditis elegans)
PIP3:RhoA [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
ROCK1,ROCK2 are activated (Caenorhabditis elegans)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
Signaling by Rho GTPases (Caenorhabditis elegans)
RHO GTPase Effectors (Caenorhabditis elegans)
RHO GTPases Activate Formins (Caenorhabditis elegans)
DIAPH1 binds RHOA:GTP (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP:DIAPH1 [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHO GTPases Activate ROCKs (Caenorhabditis elegans)
ROCK activation by RHO (Caenorhabditis elegans)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHO GTPases Activate Rhotekin and Rhophilins (Caenorhabditis elegans)
RHOA:GTP:RTKN binds LIN7B (Caenorhabditis elegans)
RHOA:GTP:RTKN [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP:RTKN:LIN7B [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP:RTKN binds TAX1BP3 (Caenorhabditis elegans)
RHOA:GTP:RTKN [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP:RTKN:TAX1BP3 [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP:RTKN [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHO GTPases activate PKNs (Caenorhabditis elegans)
PDPK1 phosphorylates PKN1,2,3 (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3 [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3 [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3 [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3 [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHO GTPase cycle (Caenorhabditis elegans)
RHOA GTPase cycle (Caenorhabditis elegans)
GDIs block activation of RHOA (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA GAPs stimulate RHOA GTPase activity (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA GEFs activate RHOA (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA binds effectors at the plasma membrane (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP:cytosolic RHOA effectors [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP translocates to the ER membrane (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA [plasma membrane] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:Q22038
Reference Genes
BioGPS Gene:178458
ENSEMBL:WBGene00004357
KEGG:cel:CELE_Y51H4A.3
Monarch:178458
NCBI Gene:178458
UCSC:Q22038
Wormbase:WBGene00004357
Reference Transcript
RefSeq:NM_070558.6
Other Identifiers
173426_at
174946_at
178458
18558739
193142_s_at
A_12_P108693
CE25369
CE_WBGene00004357_A
CGZ0048016
GO:0000915
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005938
GO:0007010
GO:0007015
GO:0007165
GO:0007264
GO:0014057
GO:0016477
GO:0016787
GO:0019901
GO:0030241
GO:0031034
GO:0032154
GO:0032794
GO:0032956
GO:0032970
GO:0040017
GO:0043226
GO:0048870
GO:0051301
GO:0065003
WBGene00004357
Y51H4A.3
Y51H4A.3_267-326_0.923_15_C
Y51H4A.3_369-428_0.949_2_B
Y51H4A.3_405-464_0.949_1_A
Y51H4A_3P00063
Y51H4A_3P00187
Y51H4A_3P00480
cea2.c.31959
Participates
as a member of
Secretory granule membrane proteins [plasma membrane] (Caenorhabditis elegans)
Ficolin-rich granule membrane proteins [plasma membrane] (Caenorhabditis elegans)
RHOA/B/C [plasma membrane] (Caenorhabditis elegans)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Caenorhabditis elegans)
as an input of
PIP3 binds to RhoA and activates it (Caenorhabditis elegans)
as a component of
PIP3:RhoA [plasma membrane] (Caenorhabditis elegans)
RHOA:GDP [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP [plasma membrane] (Caenorhabditis elegans)
Other forms of this molecule
RHOD [mitochondrial outer membrane]
RHOD [cytosol]
RHOD [plasma membrane]
RHOD [Golgi membrane]
RHOA [endoplasmic reticulum membrane]
RHOF [plasma membrane]
RHOF [secretory granule membrane]
RHOA [secretory granule membrane]
RHOA [ficolin-1-rich granule membrane]
RHOB [endosome membrane]
RHOD [endosome membrane]
RHOB [cytosol]
RHOA [cytosol]
RHOA [cell junction]
RHOB [plasma membrane]
Inferred From
RHOA [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_502959.1
ENSEMBL
Y51H4A.3a.1
PRO
Q22038
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6P5Z2 PKN3
2
p-T718-PKN3 [cytosol]
(R-HSA-5623654)
PKN3 [cytosol]
(R-HSA-5623611)
0.544
2
UniProt:Q28021 ROCK2
1
ROCK2 [cytosol]
(R-BTA-419911)
0.508
2
UniProt:O44770 KATIP
0.488
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text