Reactome | phospho-crh-1 [nucleoplasm]

phospho-crh-1 [nucleoplasm]

Stable Identifier

R-CEL-199897

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

p-S63-ATF1, D0Z5N1

Locations in the PathwayBrowser

Expand all

Immune System (Caenorhabditis elegans)

- Cytokine Signaling in Immune system (Caenorhabditis elegans)
  - Signaling by Interleukins (Caenorhabditis elegans)
    - Interleukin-17 signaling (Caenorhabditis elegans)
      - MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)
- Innate Immune System (Caenorhabditis elegans)
  - Toll-like Receptor Cascades (Caenorhabditis elegans)
    - Toll Like Receptor 10 (TLR10) Cascade (Caenorhabditis elegans)
      - MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 2 (TLR2) Cascade (Caenorhabditis elegans)
      - Toll Like Receptor TLR1:TLR2 Cascade (Caenorhabditis elegans)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)
      - Toll Like Receptor TLR6:TLR2 Cascade (Caenorhabditis elegans)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 3 (TLR3) Cascade (Caenorhabditis elegans)
      - MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 4 (TLR4) Cascade (Caenorhabditis elegans)
      - MyD88-independent TLR4 cascade (Caenorhabditis elegans)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 5 (TLR5) Cascade (Caenorhabditis elegans)
      - MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Caenorhabditis elegans)
      - MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 9 (TLR9) Cascade (Caenorhabditis elegans)
      - MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
  - Signaling by NTRKs (Caenorhabditis elegans)
    - Signaling by NTRK1 (TRKA) (Caenorhabditis elegans)
      - Nuclear Events (kinase and transcription factor activation) (Caenorhabditis elegans)
        
        CREB phosphorylation (Caenorhabditis elegans)
        
        MSK1 activates ATF1 (Caenorhabditis elegans)
        
        phospho-crh-1 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:D0Z5N1

Gene Names

crh-1

Reference Genes

BioGPS Gene:176597 crh-1

ENSEMBL:WBGene00000793

Monarch:176597 crh-1

NCBI Gene:176597 crh-1

Wormbase:WBGene00000793

Reference Transcript

RefSeq:NM_001268206.1 crh-1

Other Identifiers

176597

181128_at

18517272

189423_s_at

A_12_P111958

A_12_P112504

A_12_P131910

A_12_P131911

A_12_P131912

A_12_P131913

A_12_P131914

CE32253

CE_WBGene00000793_A

CE_WBGene00000793_B

CGZ0045460

CGZ0045462

GO:0000978

GO:0000981

GO:0001223

GO:0003674

GO:0003677

GO:0003700

GO:0005575

GO:0005622

GO:0005634

GO:0005667

GO:0006355

GO:0006357

GO:0007165

GO:0007568

GO:0008134

GO:0008150

GO:0008340

GO:0009058

GO:0032991

GO:0034641

GO:0035556

GO:0042802

GO:0043226

GO:0048856

WBGene00000793

Y41C4A.3

Y41C4A.4

Y41C4A.4d_794-853_0.917_7_A

Y41C4A.4d_907-966_0.821_29_B

Y41C4A_4aP00729

cea2.d.06625

cea2.i.21805

Participates

as an output of

MSK1 activates ATF1 (Caenorhabditis elegans)

Other forms of this molecule

crh-1 [nucleoplasm]

phospho-crh-1 [nucleoplasm]

Inferred From

p-S63-ATF1 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 63 (in Homo sapiens)

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001255135.1

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:D0Z5N1	4	phospho-crh-1 [nucleoplasm] (R-CEL-199897) crh-1 [nucleoplasm] (R-CEL-199900) crh-1 [nucleoplasm] (R-CEL-52777) phospho-crh-1 [nucleoplasm] (R-CEL-111910)	0.592	2

Cite Us!