Reactome | aakg-2 [cytosol]

aakg-2 [cytosol]

Stable Identifier

R-CEL-200419-3

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

PRKAG2, O02168

Locations in the PathwayBrowser

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Autophagy (Caenorhabditis elegans)

- Macroautophagy (Caenorhabditis elegans)
  - AMPK (complex) phosphorylates ULK1 (complex) (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK gamma [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAG2 [cytosol] (Caenorhabditis elegans)
        
        aakg-2 [cytosol] (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK gamma [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAG2 [cytosol] (Caenorhabditis elegans)
        
        aakg-2 [cytosol] (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK gamma [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAG2 [cytosol] (Caenorhabditis elegans)
        
        aakg-2 [cytosol] (Caenorhabditis elegans)
  - Thr-180 of ULK1 is phosphorylated (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK gamma [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAG2 [cytosol] (Caenorhabditis elegans)
        
        aakg-2 [cytosol] (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK gamma [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAG2 [cytosol] (Caenorhabditis elegans)
        
        aakg-2 [cytosol] (Caenorhabditis elegans)
  - ULK complex translocates to the ER (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK gamma [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAG2 [cytosol] (Caenorhabditis elegans)
        
        aakg-2 [cytosol] (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK gamma [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAG2 [cytosol] (Caenorhabditis elegans)
        
        aakg-2 [cytosol] (Caenorhabditis elegans)
  - ULK1 phosphorylates AMBRA1:BECN1 complex (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK gamma [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAG2 [cytosol] (Caenorhabditis elegans)
        
        aakg-2 [cytosol] (Caenorhabditis elegans)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK gamma [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAG2 [cytosol] (Caenorhabditis elegans)
        
        aakg-2 [cytosol] (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK gamma [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAG2 [cytosol] (Caenorhabditis elegans)
        
        aakg-2 [cytosol] (Caenorhabditis elegans)
  - ULK1 phosphorylates Beclin-1 (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK gamma [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAG2 [cytosol] (Caenorhabditis elegans)
        
        aakg-2 [cytosol] (Caenorhabditis elegans)
  - p-AMPK:AMP binds the ULK complex (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK gamma [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAG2 [cytosol] (Caenorhabditis elegans)
        
        aakg-2 [cytosol] (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK gamma [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAG2 [cytosol] (Caenorhabditis elegans)
        
        aakg-2 [cytosol] (Caenorhabditis elegans)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Caenorhabditis elegans)
    - p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
      - p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK gamma [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAG2 [cytosol] (Caenorhabditis elegans)
        
        aakg-2 [cytosol] (Caenorhabditis elegans)

Gene expression (Transcription) (Caenorhabditis elegans)

- RNA Polymerase II Transcription (Caenorhabditis elegans)
  - Generic Transcription Pathway (Caenorhabditis elegans)
    - Transcriptional Regulation by TP53 (Caenorhabditis elegans)
      - TP53 Regulates Metabolic Genes (Caenorhabditis elegans)
        
        SESN1,2,3 bind AMPK (Caenorhabditis elegans)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK gamma [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAG2 [cytosol] (Caenorhabditis elegans)
        
        aakg-2 [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer:AMP [cytosol] (Caenorhabditis elegans)
        
        p-AMPK heterotrimer [cytosol] (Caenorhabditis elegans)
        
        AMPK gamma [cytosol] (Caenorhabditis elegans)
        
        Homologues of PRKAG2 [cytosol] (Caenorhabditis elegans)
        
        aakg-2 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:O02168

Gene Names

aakg-2

Reference Genes

BioGPS Gene:181736 aakg-2

CTD Gene:181736 aakg-2

ENSEMBL:WBGene00020633

Monarch:181736 aakg-2

NCBI Gene:181736 aakg-2

UCSC:O02168 aakg-2

Wormbase:WBGene00020633

Reference Transcript

RefSeq:NM_078324.5 aakg-2

Other Identifiers

173076_s_at

181736

18631921

191715_at

A_12_P117360

CE29350

CE_WBGene00020633_A

CGZ0035750

T20F7.6

T20F7.6_628-687_0.923_13_A

T20F7.6_737-796_0.882_28_C

T20F7.6_806-865_0.915_14_B

T20F7_6P00122

T20F7_6P01032

T20F7_6P01189

WBGene00020633

cea2.p.154486

Participates

as a member of

Homologues of PRKAG2 [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

aakg-2 [nucleoplasm]

aakg-2 [cytosol]

Inferred From

PRKAG2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_510725.1

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