Reactome | dlg-1 [plasma membrane]

dlg-1 [plasma membrane]

Stable Identifier

R-CEL-202135

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

plasma membrane

Synonyms

DLG4, G5ECY0

Locations in the PathwayBrowser

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Neuronal System (Caenorhabditis elegans)

- Protein-protein interactions at synapses (Caenorhabditis elegans)
  - Synaptic adhesion-like molecules (Caenorhabditis elegans)
    - PSD-95 binds NMDA receptor (Caenorhabditis elegans)
      - NMDAR:PSD-95 [plasma membrane] (Caenorhabditis elegans)
        
        dlg-1 [plasma membrane] (Caenorhabditis elegans)
      - dlg-1 [plasma membrane] (Caenorhabditis elegans)
    - SALM1 binds NMDA receptor (Caenorhabditis elegans)
      - NMDAR:PSD-95 [plasma membrane] (Caenorhabditis elegans)
        
        dlg-1 [plasma membrane] (Caenorhabditis elegans)
      - SALM1:NMDAR:PSD-95 [plasma membrane] (Caenorhabditis elegans)
        
        NMDAR:PSD-95 [plasma membrane] (Caenorhabditis elegans)
        
        dlg-1 [plasma membrane] (Caenorhabditis elegans)
- Transmission across Chemical Synapses (Caenorhabditis elegans)
  - Neurotransmitter receptors and postsynaptic signal transmission (Caenorhabditis elegans)
    - Activation of NMDA receptors and postsynaptic events (Caenorhabditis elegans)
      - Unblocking of NMDA receptors, glutamate binding and activation (Caenorhabditis elegans)
        
        Ca2+ influx into the post-synaptic cell (Caenorhabditis elegans)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Caenorhabditis elegans)
        
        dlg-1 [plasma membrane] (Caenorhabditis elegans)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Caenorhabditis elegans)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Caenorhabditis elegans)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Caenorhabditis elegans)
        
        dlg-1 [plasma membrane] (Caenorhabditis elegans)
    - Activation of kainate receptors upon glutamate binding (Caenorhabditis elegans)
      - Ionotropic activity of kainate receptors (Caenorhabditis elegans)
        
        Activation of Ca-permeable Kainate Receptor (Caenorhabditis elegans)
        
        Activation of Ca-permeable Kainate receptors (Caenorhabditis elegans)
        
        Kainate receptor-glutamate complex [plasma membrane] (Caenorhabditis elegans)
        
        GRIK 2 homomer [plasma membrane] (Caenorhabditis elegans)
        
        GRIK2 interacting proteins [plasma membrane] (Caenorhabditis elegans)
        
        dlg-1 [plasma membrane] (Caenorhabditis elegans)
        
        kainate receptor binds glutamate (Caenorhabditis elegans)
        
        GRIK 2 homomer [plasma membrane] (Caenorhabditis elegans)
        
        GRIK2 interacting proteins [plasma membrane] (Caenorhabditis elegans)
        
        dlg-1 [plasma membrane] (Caenorhabditis elegans)
        
        Kainate receptor-glutamate complex [plasma membrane] (Caenorhabditis elegans)
        
        GRIK 2 homomer [plasma membrane] (Caenorhabditis elegans)
        
        GRIK2 interacting proteins [plasma membrane] (Caenorhabditis elegans)
        
        dlg-1 [plasma membrane] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:G5ECY0

Gene Names

dlg-1

Reference Genes

BioGPS Gene:180819 dlg-1

CTD Gene:180819 dlg-1

ENSEMBL:WBGene00001006

KEGG:cel:CELE_C25F6.2 dlg-1

Monarch:180819 dlg-1

NCBI Gene:180819 dlg-1

UCSC:G5ECY0 dlg-1

Wormbase:WBGene00001006

Reference Transcript

Other Identifiers

174906_s_at

180819

18604673

191562_at

A_12_P109127

A_12_P151810

C25F6.2

C25F6.2a_2449-2508_0.938_5_B

C25F6.2a_2593-2652_0.929_6_C

C25F6.2a_2774-2833_0.960_1_A

C25F6_2aP01909

C25F6_2aP02275

C25F6_2aP02735

C25F6_2bP00099

C25F6_2bP00749

C25F6_2bP01046

CE26970

CE_WBGene00001006_A

CE_WBGene00001006_B

CGZ0005929

GO:0003824

GO:0004385

GO:0005515

GO:0005737

GO:0005886

GO:0005912

GO:0007155

GO:0007163

GO:0007268

GO:0009792

GO:0016323

GO:0016324

GO:0016328

GO:0016740

GO:0019901

GO:0023052

GO:0030054

GO:0031594

GO:0034330

GO:0043005

GO:0043113

GO:0043296

GO:0045186

GO:0045197

GO:0046037

GO:0046710

GO:0048856

GO:0055086

GO:0070161

GO:0097120

GO:0098609

GO:0098839

GO:0099072

GO:1901135

WBGene00001006

cea2.p.134973

Participates

as a component of

as an input of

PSD-95 binds NMDA receptor (Caenorhabditis elegans)

Other forms of this molecule

dlg-1 [cytosol]

dlg-1 [plasma membrane]

Inferred From

DLG4 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001024432.1, NP_001024431.1

ENSEMBL

C25F6.2.1

PRO

G5ECY0

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:G5ECG0 TACC1			0.635	3
UniProt:Q18426	4	prx-5 [cytosol] (R-CEL-9033510) prx-5 [cytosol] (R-CEL-9033103) prx-5 [peroxisomal membrane] (R-CEL-9033501) prx-5 [peroxisomal membrane] (R-CEL-9033489)	0.57	4
UniProt:P91820 P91820			0.553	2
UniProt:H2L055	3	phospho-p-S7-RAP1GAP2 [cytosol] (R-CEL-913989) RAP1GAP2 [cytosol] (R-CEL-392491) RAP1GAP [cytosol] (R-CEL-392493)	0.508	2