Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
let-502 [cytosol]
Stable Identifier
R-CEL-212509
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
cytosol
Synonyms
ROCK1, P92199
Locations in the PathwayBrowser
Expand all
Developmental Biology (Caenorhabditis elegans)
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
EPH-Ephrin signaling (Caenorhabditis elegans)
EPHB-mediated forward signaling (Caenorhabditis elegans)
RHOA:GTP binds ROCK, activating it (Caenorhabditis elegans)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
Semaphorin interactions (Caenorhabditis elegans)
Sema4D in semaphorin signaling (Caenorhabditis elegans)
Sema4D induced cell migration and growth-cone collapse (Caenorhabditis elegans)
ROCK activation by RHO (Caenorhabditis elegans)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
ROCK1,ROCK2:ROCKi [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
ROCK1,2 bind ROCKi (Caenorhabditis elegans)
ROCK1,ROCK2:ROCKi [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
Programmed Cell Death (Caenorhabditis elegans)
Apoptosis (Caenorhabditis elegans)
Apoptotic execution phase (Caenorhabditis elegans)
Apoptotic cleavage of cellular proteins (Caenorhabditis elegans)
Caspase-mediated cleavage of Rock-1 (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (12/13) signalling events (Caenorhabditis elegans)
ROCK activation by RHO (Caenorhabditis elegans)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
ROCK1,ROCK2:ROCKi [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
ROCK1,2 bind ROCKi (Caenorhabditis elegans)
ROCK1,ROCK2:ROCKi [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Caenorhabditis elegans)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
ROCK1,ROCK2 are activated (Caenorhabditis elegans)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
RHOA:GTP:Mg2+:Activated ROCK1,ROCK2 [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
Signaling by Rho GTPases (Caenorhabditis elegans)
RHO GTPase Effectors (Caenorhabditis elegans)
RHO GTPases Activate ROCKs (Caenorhabditis elegans)
ROCK activation by RHO (Caenorhabditis elegans)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
ROCK1,ROCK2:ROCKi [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
ROCK1,2 bind ROCKi (Caenorhabditis elegans)
ROCK1,ROCK2:ROCKi [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
RHO GTPase cycle (Caenorhabditis elegans)
RHOA GTPase cycle (Caenorhabditis elegans)
RHOA binds effectors at the plasma membrane (Caenorhabditis elegans)
RHOA plasma membrane effectors [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
RHOA:GTP:cytosolic RHOA effectors [plasma membrane] (Caenorhabditis elegans)
RHOA plasma membrane effectors [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
RHOB GTPase cycle (Caenorhabditis elegans)
RHOB binds effectors at the plasma membrane (Caenorhabditis elegans)
RHOB effectors (plasma membrane) [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
RHOB:GTP:cytosolic RHOB effectors [plasma membrane] (Caenorhabditis elegans)
RHOB effectors (plasma membrane) [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
RHOH GTPase cycle (Caenorhabditis elegans)
RHOH binds effectors at the plasma membrane (Caenorhabditis elegans)
RHOH effectors [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
RHOH:GTP:RHOH effectors [plasma membrane] (Caenorhabditis elegans)
RHOH effectors [cytosol] (Caenorhabditis elegans)
let-502 [cytosol] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:P92199
Gene Names
let-502
Reference Genes
BioGPS Gene:172088 let-502
CTD Gene:172088 let-502
ENSEMBL:WBGene00002694
KEGG:cel:CELE_C10H11.9 let-502
Monarch:172088 let-502
NCBI Gene:172088 let-502
UCSC:P92199 let-502
Wormbase:WBGene00002694
Wormbase:WBGene00002694 let-502
Reference Transcript
RefSeq:NM_059039.8 let-502
Other Identifiers
172088
GO:0000281
GO:0000910
GO:0002119
GO:0003824
GO:0004672
GO:0004674
GO:0004676
GO:0004677
GO:0004679
GO:0004694
GO:0004711
GO:0005524
GO:0005634
GO:0005737
GO:0005856
GO:0005912
GO:0006325
GO:0006338
GO:0006468
GO:0007010
GO:0007266
GO:0008270
GO:0008360
GO:0009792
GO:0010172
GO:0016740
GO:0022414
GO:0030154
GO:0030866
GO:0031032
GO:0031267
GO:0032154
GO:0032956
GO:0035175
GO:0035402
GO:0035403
GO:0035979
GO:0043226
GO:0043292
GO:0044022
GO:0044023
GO:0044024
GO:0044025
GO:0048477
GO:0048598
GO:0048856
GO:0072354
GO:0072371
GO:0072518
GO:0106310
GO:0140096
GO:0140823
GO:0140855
GO:0140857
GO:0160094
GO:1901888
GO:1905905
GO:1990244
Participates
as a member of
RHOA plasma membrane effectors [cytosol] (Caenorhabditis elegans)
RHOB effectors (plasma membrane) [cytosol] (Caenorhabditis elegans)
as a candidate of
RHOH effectors [cytosol] (Caenorhabditis elegans)
as an input of
RHOA:GTP binds ROCK, activating it (Caenorhabditis elegans)
ROCK1,2 bind ROCKi (Caenorhabditis elegans)
ROCK activation by RHO (Caenorhabditis elegans)
RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Caenorhabditis elegans)
Caspase-mediated cleavage of Rock-1 (Caenorhabditis elegans)
as a component of
ROCK1,ROCK2:ROCKi [cytosol] (Caenorhabditis elegans)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Caenorhabditis elegans)
RHOA:GTP:Mg2+:Activated ROCK1,ROCK2 [cytosol] (Caenorhabditis elegans)
Other forms of this molecule
let-502 [extracellular region]
let-502 [secretory granule lumen]
let-502 [cytosol]
let-502 [cytosol]
let-502 [cytosol]
Inferred From
ROCK1,ROCK2 [cytosol]
(Homo sapiens)
Activated ROCK1,ROCK2 [cytosol]
(Homo sapiens)
Activated ROCK1 [cytosol]
(Homo sapiens)
ROCK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_491440.1
ENSEMBL
WBGene00002694
,
C10H11.9.1
,
C10H11.9.1
PRO
P92199
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text