Reactome | ITGB5 [plasma membrane]

ITGB5 [plasma membrane]

Stable Identifier

R-CEL-215948-2

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

plasma membrane

Synonyms

Q9GYK2

Locations in the PathwayBrowser

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Extracellular matrix organization (Caenorhabditis elegans)

- Elastic fibre formation (Caenorhabditis elegans)
  - Molecules associated with elastic fibres (Caenorhabditis elegans)
    - Latent TGF-beta-1 binds integrins (Caenorhabditis elegans)
      - LAP1 binding-integrins [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta5 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)
      - LTBP1:TGFB1:LAP1:LAP1-binding integrins [plasma membrane] (Caenorhabditis elegans)
        
        LAP1 binding-integrins [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta5 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)
    - Latent TGF-beta-3 binds integrins (Caenorhabditis elegans)
      - LAP3-binding integrins [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta5 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)
      - TGF-beta-3:LAP3:LAP3-binding integrins [plasma membrane] (Caenorhabditis elegans)
        
        LAP3-binding integrins [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta5 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)
- Integrin cell surface interactions (Caenorhabditis elegans)
  - Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Caenorhabditis elegans)
    - Canstatin:Integrins alphaVbeta3, alphaVbeta5 [plasma membrane] (Caenorhabditis elegans)
      - Integrins alphaVbeta3, alphaVbeta5 [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta5 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)
    - Integrins alphaVbeta3, alphaVbeta5 [plasma membrane] (Caenorhabditis elegans)
      - Integrin alphaVbeta5 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)
- Non-integrin membrane-ECM interactions (Caenorhabditis elegans)
  - Syndecan interactions (Caenorhabditis elegans)
    - Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Caenorhabditis elegans)
      - Integrin alpha2beta1, (alpha6beta4) [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta5 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)
      - Syndecan-1:Integrin alpha2beta1 (alpha6beta4) [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alpha2beta1, (alpha6beta4) [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta5 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)

Immune System (Caenorhabditis elegans)

- Adaptive Immune System (Caenorhabditis elegans)
  - Class I MHC mediated antigen processing & presentation (Caenorhabditis elegans)
    - Antigen processing-Cross presentation (Caenorhabditis elegans)
      - Cross-presentation of particulate exogenous antigens (phagosomes) (Caenorhabditis elegans)
        
        Engulfment of particulate antigen into phagocytic vesicle (Caenorhabditis elegans)
        
        Particulate Ag:DC receptors [plasma membrane] (Caenorhabditis elegans)
        
        DC receptors recognizing apoptotic cells [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta5 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        Interaction of particulate antigens with dendritic cell receptors (Caenorhabditis elegans)
        
        DC receptors recognizing apoptotic cells [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta5 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        Particulate Ag:DC receptors [plasma membrane] (Caenorhabditis elegans)
        
        DC receptors recognizing apoptotic cells [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta5 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)

Muscle contraction (Caenorhabditis elegans)

- Smooth Muscle Contraction (Caenorhabditis elegans)
  - ATP Hydrolysis By Myosin (Caenorhabditis elegans)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Caenorhabditis elegans)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Caenorhabditis elegans)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)
  - Calcium Binds Caldesmon (Caenorhabditis elegans)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Caenorhabditis elegans)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)
    - Inactive Myosin Actin Contractile Complex [plasma membrane] (Caenorhabditis elegans)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)
  - Myosin Binds ATP (Caenorhabditis elegans)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Caenorhabditis elegans)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)
    - p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Caenorhabditis elegans)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)
  - Release Of ADP From Myosin (Caenorhabditis elegans)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Caenorhabditis elegans)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Caenorhabditis elegans)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by TGFB family members (Caenorhabditis elegans)
  - Signaling by TGF-beta Receptor Complex (Caenorhabditis elegans)
    - TGF-beta receptor signaling activates SMADs (Caenorhabditis elegans)
      - Latent TGF-beta-1 binds integrins (Caenorhabditis elegans)
        
        LAP1 binding-integrins [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta5 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        LTBP1:TGFB1:LAP1:LAP1-binding integrins [plasma membrane] (Caenorhabditis elegans)
        
        LAP1 binding-integrins [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta5 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)
      - Latent TGF-beta-3 binds integrins (Caenorhabditis elegans)
        
        LAP3-binding integrins [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta5 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        TGF-beta-3:LAP3:LAP3-binding integrins [plasma membrane] (Caenorhabditis elegans)
        
        LAP3-binding integrins [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta5 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB5 [plasma membrane] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9GYK2

Reference Genes

BioGPS Gene:182254

CTD Gene:182254

ENSEMBL:WBGene00015472

Monarch:182254

NCBI Gene:182254

UCSC:Q9GYK2

Wormbase:WBGene00015472

Reference Transcript

RefSeq:NM_075811.5

Other Identifiers

182254

183557_at

18603055

A_12_P108808

C05D9.3

C05D9.3_688-747_0.881_13_A

C05D9.3_768-827_0.792_59_C

C05D9.3_844-903_0.850_23_B

C05D9_3P00109

C05D9_3P00566

C05D9_3P00958

CE30852

CE_WBGene00015472_A

CE_WBGene00015472_B

CE_WBGene00015472_C

CGZ0002632

GO:0005886

GO:0007229

GO:0016020

WBGene00015472

cea2.p.132807

Participates

as a member of

Homologues of ITGB5 [plasma membrane] (Caenorhabditis elegans)

Other forms of this molecule

phospho-p-T779-ITGB3 [plasma membrane]

ITGB3(27-?) [platelet alpha granule membrane]

ITGB5 [phagocytic vesicle]

ITGB2 [tertiary granule membrane]

ITGB2 [specific granule membrane]

ITGB2 [ficolin-1-rich granule membrane]

ITGB4 [plasma membrane]

ITGB2 [plasma membrane]

ITGB7 [plasma membrane]

ITGB1 [plasma membrane]

ITGB6 [plasma membrane]

ITGB8 [plasma membrane]

ITGB3 [plasma membrane]

Inferred From

ITGB5 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_508212.3

ENSEMBL

C05D9.3a.1

PRO

Q9GYK2

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q965W3 Q965W3			0.488	2

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