Reactome | ITGB6 [plasma membrane]

ITGB6 [plasma membrane]

Stable Identifier

R-CEL-215951-2

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

plasma membrane

Synonyms

Q9GYK2

Locations in the PathwayBrowser

Expand all

Extracellular matrix organization (Caenorhabditis elegans)

- ECM proteoglycans (Caenorhabditis elegans)
  - TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Caenorhabditis elegans)
    - Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 [plasma membrane] (Caenorhabditis elegans)
      - Integrin alphaVbeta6 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB6 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB6 [plasma membrane] (Caenorhabditis elegans)
    - TNC:Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 [plasma membrane] (Caenorhabditis elegans)
      - Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta6 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB6 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB6 [plasma membrane] (Caenorhabditis elegans)
- Elastic fibre formation (Caenorhabditis elegans)
  - Molecules associated with elastic fibres (Caenorhabditis elegans)
    - Latent TGF-beta-1 binds integrins (Caenorhabditis elegans)
      - LAP1 binding-integrins [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta6 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB6 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB6 [plasma membrane] (Caenorhabditis elegans)
      - LTBP1:TGFB1:LAP1:LAP1-binding integrins [plasma membrane] (Caenorhabditis elegans)
        
        LAP1 binding-integrins [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta6 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB6 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB6 [plasma membrane] (Caenorhabditis elegans)
    - Latent TGF-beta-3 binds integrins (Caenorhabditis elegans)
      - LAP3-binding integrins [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta6 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB6 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB6 [plasma membrane] (Caenorhabditis elegans)
      - TGF-beta-3:LAP3:LAP3-binding integrins [plasma membrane] (Caenorhabditis elegans)
        
        LAP3-binding integrins [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta6 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB6 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB6 [plasma membrane] (Caenorhabditis elegans)
- Integrin cell surface interactions (Caenorhabditis elegans)
  - Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Caenorhabditis elegans)
    - Integrin alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 [plasma membrane] (Caenorhabditis elegans)
      - Integrin alphaVbeta6 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB6 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB6 [plasma membrane] (Caenorhabditis elegans)
    - Integrin alpha4beta1, alpha8beta1, alphaVbeta6:Fibronectin matrix [plasma membrane] (Caenorhabditis elegans)
      - Integrin alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta6 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB6 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB6 [plasma membrane] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by TGFB family members (Caenorhabditis elegans)
  - Signaling by TGF-beta Receptor Complex (Caenorhabditis elegans)
    - TGF-beta receptor signaling activates SMADs (Caenorhabditis elegans)
      - Latent TGF-beta-1 binds integrins (Caenorhabditis elegans)
        
        LAP1 binding-integrins [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta6 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB6 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB6 [plasma membrane] (Caenorhabditis elegans)
        
        LTBP1:TGFB1:LAP1:LAP1-binding integrins [plasma membrane] (Caenorhabditis elegans)
        
        LAP1 binding-integrins [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta6 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB6 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB6 [plasma membrane] (Caenorhabditis elegans)
      - Latent TGF-beta-3 binds integrins (Caenorhabditis elegans)
        
        LAP3-binding integrins [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta6 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB6 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB6 [plasma membrane] (Caenorhabditis elegans)
        
        TGF-beta-3:LAP3:LAP3-binding integrins [plasma membrane] (Caenorhabditis elegans)
        
        LAP3-binding integrins [plasma membrane] (Caenorhabditis elegans)
        
        Integrin alphaVbeta6 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of ITGB6 [plasma membrane] (Caenorhabditis elegans)
        
        ITGB6 [plasma membrane] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9GYK2

Reference Genes

BioGPS Gene:182254

CTD Gene:182254

ENSEMBL:WBGene00015472

Monarch:182254

NCBI Gene:182254

UCSC:Q9GYK2

Wormbase:WBGene00015472

Reference Transcript

RefSeq:NM_075811.5

Other Identifiers

182254

183557_at

18603055

A_12_P108808

C05D9.3

C05D9.3_688-747_0.881_13_A

C05D9.3_768-827_0.792_59_C

C05D9.3_844-903_0.850_23_B

C05D9_3P00109

C05D9_3P00566

C05D9_3P00958

CE30852

CE_WBGene00015472_A

CE_WBGene00015472_B

CE_WBGene00015472_C

CGZ0002632

GO:0005886

GO:0007229

GO:0016020

GO:0023052

WBGene00015472

cea2.p.132807

Participates

as a member of

Homologues of ITGB6 [plasma membrane] (Caenorhabditis elegans)

Other forms of this molecule

phospho-p-T779-ITGB3 [plasma membrane]

ITGB3(27-?) [platelet alpha granule membrane]

ITGB2 [specific granule membrane]

ITGB2 [ficolin-1-rich granule membrane]

ITGB2 [tertiary granule membrane]

ITGB5 [phagocytic vesicle]

ITGB4 [plasma membrane]

ITGB7 [plasma membrane]

ITGB2 [plasma membrane]

ITGB1 [plasma membrane]

ITGB5 [plasma membrane]

ITGB8 [plasma membrane]

ITGB3 [plasma membrane]

Inferred From

ITGB6 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_508212.3

PRO

Q9GYK2

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q965W3 Q965W3			0.488	2

Cite Us!