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phospho-p-T,Y-MAPK8 [nucleoplasm]
Stable Identifier
R-CEL-216349
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
nucleoplasm
Synonyms
Q8WQG9
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular Senescence (Caenorhabditis elegans)
Oxidative Stress Induced Senescence (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Activated human JNKs migrate to nucleoplasm (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Immune System (Caenorhabditis elegans)
Cytokine Signaling in Immune system (Caenorhabditis elegans)
Signaling by Interleukins (Caenorhabditis elegans)
Interleukin-17 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Activated human JNKs migrate to nucleoplasm (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Innate Immune System (Caenorhabditis elegans)
Fc epsilon receptor (FCERI) signaling (Caenorhabditis elegans)
FCERI mediated MAPK activation (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Activated human JNKs migrate to nucleoplasm (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Toll-like Receptor Cascades (Caenorhabditis elegans)
Toll Like Receptor 10 (TLR10) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Activated human JNKs migrate to nucleoplasm (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor 2 (TLR2) Cascade (Caenorhabditis elegans)
Toll Like Receptor TLR1:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Activated human JNKs migrate to nucleoplasm (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor TLR6:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Activated human JNKs migrate to nucleoplasm (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor 3 (TLR3) Cascade (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Activated human JNKs migrate to nucleoplasm (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor 4 (TLR4) Cascade (Caenorhabditis elegans)
MyD88-independent TLR4 cascade (Caenorhabditis elegans)
TRIF (TICAM1)-mediated TLR4 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Activated human JNKs migrate to nucleoplasm (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Activated human JNKs migrate to nucleoplasm (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor 5 (TLR5) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Activated human JNKs migrate to nucleoplasm (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Activated human JNKs migrate to nucleoplasm (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor 9 (TLR9) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Activated human JNKs migrate to nucleoplasm (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
Activation of the AP-1 family of transcription factors (Caenorhabditis elegans)
Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Caenorhabditis elegans)
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
Death Receptor Signaling (Caenorhabditis elegans)
p75 NTR receptor-mediated signalling (Caenorhabditis elegans)
Cell death signalling via NRAGE, NRIF and NADE (Caenorhabditis elegans)
NRAGE signals death through JNK (Caenorhabditis elegans)
Active JNK moves to the nucleus and phosphorylates different transcription factors (Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:Q8WQG9
Reference Genes
BioGPS Gene:177460
CTD Gene:177460
ENSEMBL:WBGene00002178
KEGG:cel:CELE_B0478.1
Monarch:177460
NCBI Gene:177460
UCSC:Q8WQG9
Wormbase:WBGene00002178
Reference Transcript
RefSeq:NM_001026099.3
RefSeq:NM_171371.4
Other Identifiers
175640_at
177460
18532534
190415_s_at
A_12_P102374
A_12_P106773
B0478.1
B0478.1a
B0478.1a_1101-1160_0.937_3_B
B0478.1a_1181-1240_0.926_8_C
B0478.1a_1361-1420_0.960_1_A
B0478.1a_833
B0478.1b
B0478_1aP00012
B0478_1aP00182
B0478_1aP00204
B0478_1bP00092
B0478_1bP00659
B0478_1bP00834
CE27574
CE30123
CE_WBGene00002178_A
CE_WBGene00002178_B
CGZ0001202
GO:0000165
GO:0003824
GO:0004672
GO:0004674
GO:0004705
GO:0004707
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0006468
GO:0006972
GO:0007254
GO:0008340
GO:0009408
GO:0016740
GO:0030050
GO:0030424
GO:0030431
GO:0042995
GO:0043025
GO:0043204
GO:0043226
GO:0046872
GO:0048681
GO:0061629
GO:0106310
GO:0140096
GO:1905803
WBGene00002178
cea2.d.00191
cea2.d.09640
Participates
as an output of
Active JNK moves to the nucleus and phosphorylates different transcription factors (Caenorhabditis elegans)
as a member of
p-MAPK8,9,10 [nucleoplasm] (Caenorhabditis elegans)
Other forms of this molecule
MAPK8 [cytosol]
MAPK10 [cytosol]
MAPK9 [cytosol]
phospho-p-T183,Y185-MAPK9 [cytosol]
phospho-p-T,Y-MAPK8 [cytosol]
phospho-p-T221,Y223-MAPK10 [cytosol]
phospho-p-T183,Y185-MAPK9 [nucleoplasm]
phospho-p-T221,Y223-MAPK10 [nucleoplasm]
Inferred From
p-T,Y-MAPK8 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_741434.2
,
NP_001021270.1
ENSEMBL
B0478.1a.1
PRO
Q8WQG9
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.623
3
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