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hmp-2 [nucleoplasm]
Stable Identifier
R-CEL-3451168
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
nucleoplasm
Synonyms
CTNNB1, O44326
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional Regulation by VENTX (Caenorhabditis elegans)
VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Caenorhabditis elegans)
CTNNB1:TCF7L2,LEF1:CCND1 Gene [nucleoplasm] (Caenorhabditis elegans)
TCF/LEF:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
Transcriptional regulation by RUNX3 (Caenorhabditis elegans)
RUNX3 regulates WNT signaling (Caenorhabditis elegans)
RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Caenorhabditis elegans)
RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Caenorhabditis elegans)
TCF/LEF:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
TCF/LEF:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
Signaling by WNT (Caenorhabditis elegans)
Beta-catenin independent WNT signaling (Caenorhabditis elegans)
Ca2+ pathway (Caenorhabditis elegans)
NLK phosphorylates TCF/LEF (Caenorhabditis elegans)
TCF/LEF:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
p-TCF/LEF:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
TCF dependent signaling in response to WNT (Caenorhabditis elegans)
Beta-catenin translocates to the nucleus (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
Deactivation of the beta-catenin transactivating complex (Caenorhabditis elegans)
Beta-catenin binds SOX proteins (Caenorhabditis elegans)
CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Caenorhabditis elegans)
CTNNB1:CHD8 [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
TCF:Beta-catenin binds SOX proteins (Caenorhabditis elegans)
TCF/LEF:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
TCF/LEF:CTNNB1:SOX4,SOX13,SOX17 [nucleoplasm] (Caenorhabditis elegans)
TCF/LEF:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Caenorhabditis elegans)
XPO1:YWHAZ:p-S20-CBY1:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
YWHAZ:p-S20-CBY:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
pS20-CBY1:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
beta-catenin is replaced by repression complexes at the promoter (Caenorhabditis elegans)
APC:CTBP:CTNNB1:BTRC [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
Formation of the beta-catenin:TCF transactivating complex (Caenorhabditis elegans)
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Caenorhabditis elegans)
TCF/LEF:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
Beta-catenin recruits CBP/p300 (Caenorhabditis elegans)
TCF/LEF:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
TCF/LEF:CTNNB1:CBP/p300 [nucleoplasm] (Caenorhabditis elegans)
TCF/LEF:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
Beta-catenin recruits CDC73 and LEO1 (Caenorhabditis elegans)
TCF/LEF:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
TCF/LEF:CTNNB1:PAF1-like complex [nucleoplasm] (Caenorhabditis elegans)
TCF/LEF:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
hmp-2 [nucleoplasm] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:O44326
Gene Names
hmp-2
Reference Genes
BioGPS Gene:173338 hmp-2
ENSEMBL:WBGene00001979
Monarch:173338 hmp-2
NCBI Gene:173338 hmp-2
UCSC:O44326 hmp-2
Wormbase:WBGene00001979
Reference Transcript
RefSeq:NM_001265497.1 hmp-2
Other Identifiers
173338
18457881
193907_at
A_12_P105979
CE19974
CE_WBGene00001979_A
CE_WBGene00001979_B
CE_WBGene00001979_C
CGZ0027911
GO:0005515
GO:0007155
GO:0045296
K05C4.6
K05C4.6_1085-1144_0.879_28_B
K05C4.6_1284-1343_0.903_17_A
K05C4.6_1753-1812_0.955_2_C
K05C4_6P00599
K05C4_6P00786
K05C4_6P01752
WBGene00001979
cea2.c.04836
Participates
as a component of
TCF/LEF:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
CTNNB1:CHD8 [nucleoplasm] (Caenorhabditis elegans)
CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Caenorhabditis elegans)
pS20-CBY1:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Caenorhabditis elegans)
APC:CTBP:CTNNB1:BTRC [nucleoplasm] (Caenorhabditis elegans)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] (Caenorhabditis elegans)
p-TCF/LEF:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
TCF/LEF:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
TCF7L1/TCF7L2/LEF1:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
TCF/LEF:CTNNB1 [nucleoplasm] (Caenorhabditis elegans)
as an input of
CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Caenorhabditis elegans)
Beta-catenin binds SOX proteins (Caenorhabditis elegans)
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Caenorhabditis elegans)
as an output of
Beta-catenin translocates to the nucleus (Caenorhabditis elegans)
VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Caenorhabditis elegans)
Other forms of this molecule
hmp-2 [cytosol]
hmp-2 [specific granule lumen]
hmp-2 [extracellular region]
hmp-2 [ficolin-1-rich granule lumen]
phospho-hmp-2 [nucleoplasm]
phospho-hmp-2 [cytosol]
hmp-2 [plasma membrane]
hmp-2 [plasma membrane]
phospho-hmp-2 [cytosol]
phospho-hmp-2 [cytosol]
phospho-hmp-2 [cytosol]
phospho-hmp-2 [cytosol]
hmp-2 [cytosol]
hmp-2 [cytosol]
hmp-2 [cytosol]
Inferred From
CTNNB1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001252426.1
PRO
O44326
PDB
4R10
,
5XA5
,
4R0Z
,
4R11
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q967F4 HMR1
0.785
5
UniProt:Q09506
1
txbp-3 [cytosol]
(R-CEL-5666217)
0.553
2
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