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ced-2 [cytosol]
Stable Identifier
R-CEL-354384
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
cytosol
Synonyms
CRKL, Q9NHC3
Locations in the PathwayBrowser
Expand all
Immune System (Caenorhabditis elegans)
Cytokine Signaling in Immune system (Caenorhabditis elegans)
Signaling by Interleukins (Caenorhabditis elegans)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Caenorhabditis elegans)
Regulation of signaling by CBL (Caenorhabditis elegans)
CBL binds CRK (Caenorhabditis elegans)
ced-2 [cytosol] (Caenorhabditis elegans)
p(Y700,731,774)-CBL:CRK [cytosol] (Caenorhabditis elegans)
ced-2 [cytosol] (Caenorhabditis elegans)
CBL:CRKL binds RAPGEF1 (Caenorhabditis elegans)
p(Y700,731,774)-CBL:CRK [cytosol] (Caenorhabditis elegans)
ced-2 [cytosol] (Caenorhabditis elegans)
p(Y700,731,774)-CBL:CRK:RAPGEF1 [cytosol] (Caenorhabditis elegans)
p(Y700,731,774)-CBL:CRK [cytosol] (Caenorhabditis elegans)
ced-2 [cytosol] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by MET (Caenorhabditis elegans)
MET promotes cell motility (Caenorhabditis elegans)
MET activates RAP1 and RAC1 (Caenorhabditis elegans)
CRK,CRKL recruits RAC1 GEF to activated MET (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
ced-2 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
ced-2 [cytosol] (Caenorhabditis elegans)
DOCK7 activates RAC1 (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
ced-2 [cytosol] (Caenorhabditis elegans)
GAB1 recruits CRK,CRKL to MET (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
ced-2 [cytosol] (Caenorhabditis elegans)
ced-2 [cytosol] (Caenorhabditis elegans)
RAPGEF1 activates RAP1 (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
ced-2 [cytosol] (Caenorhabditis elegans)
RAPGEF1 binds CRK,CRKL (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
ced-2 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
ced-2 [cytosol] (Caenorhabditis elegans)
MET receptor recycling (Caenorhabditis elegans)
GGA3 associates with activated MET receptor (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
ced-2 [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
ced-2 [cytosol] (Caenorhabditis elegans)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
ced-2 [cytosol] (Caenorhabditis elegans)
Signaling by PDGF (Caenorhabditis elegans)
Downstream signal transduction (Caenorhabditis elegans)
Crk binds to the active PDGF receptor (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Caenorhabditis elegans)
ced-2 [cytosol] (Caenorhabditis elegans)
ced-2 [cytosol] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:Q9NHC3
Gene Names
ced-2
Reference Genes
BioGPS Gene:176968 ced-2
ENSEMBL:WBGene00000416
Monarch:176968 ced-2
NCBI Gene:176968 ced-2
UCSC:Q9NHC3 ced-2
Wormbase:WBGene00000416
Reference Transcript
RefSeq:NM_067704.4 ced-2
Other Identifiers
175812_at
175813_s_at
176968
18544212
A_12_P112869
CE28360
CE_WBGene00000416_A
CE_WBGene00000416_B
CGZ0045498
GO:0005515
WBGene00000416
Y41D4B.13
Y41D4B.13_469-528_0.930_2_B
Y41D4B.13_691-750_0.964_1_A
Y41D4B.13_754-813_0.926_8_C
Y41D4B_13P00098
Y41D4B_13P00302
Y41D4B_13P00780
cea2.c.31854
Participates
as an input of
CBL binds CRK (Caenorhabditis elegans)
Crk binds to the active PDGF receptor (Caenorhabditis elegans)
GAB1 recruits CRK,CRKL to MET (Caenorhabditis elegans)
as a component of
p(Y700,731,774)-CBL:CRK [cytosol] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
Other forms of this molecule
ced-2 [cytosol]
Inferred From
CRK, CRKL [cytosol]
(Homo sapiens)
CRKL [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_500105.1
PRO
Q9NHC3
PDB
3QWX
,
3QWY
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