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active PDGF-AA dimer [extracellular region]
Stable Identifier
R-CEL-380761
Type
Complex
Species
Caenorhabditis elegans
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Caenorhabditis elegans)
Non-integrin membrane-ECM interactions (Caenorhabditis elegans)
HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Caenorhabditis elegans)
FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
HSPG2:FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Caenorhabditis elegans)
FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
Response to elevated platelet cytosolic Ca2+ (Caenorhabditis elegans)
Platelet degranulation (Caenorhabditis elegans)
Exocytosis of platelet alpha granule contents (Caenorhabditis elegans)
Platelet alpha granule contents [extracellular region] (Caenorhabditis elegans)
PDGF dimer [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
Activator:PI3K [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
Activator:PI3K [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
RAS GEFs promote RAS nucleotide exchange (Caenorhabditis elegans)
RAS GEFs [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by PDGF (Caenorhabditis elegans)
Autophosphorylation of PDGF alpha receptors (Caenorhabditis elegans)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Caenorhabditis elegans)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
Phospho PDGF alpha receptor:PDGF dimers [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
Downstream signal transduction (Caenorhabditis elegans)
Activation of Src (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
Crk binds to the active PDGF receptor (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
GRB2:SOS1 complex binds to the active receptor (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
Nck binds to the active PDGF receptor (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
PI3-kinase binds to the active receptor (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
Phosphorylation of PLCgamma by PDGFR (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
SH2 domain of Src binds to the active receptor (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
STAT binds to the active receptor (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
PDGF:phospho-PDGF receptor dimer:STAT [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
PDGF dimer binds two receptors simultaneously (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
PDGF:PDGF receptor dimer [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
PDGF-AA clevage by Furin (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
PDGFRs bind type I TKI (Caenorhabditis elegans)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Caenorhabditis elegans)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
active PDGF-AA dimer [extracellular region] (Caenorhabditis elegans)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
pvf-1 [extracellular region]
(Caenorhabditis elegans)
Participates
as a member of
PDGF dimer [extracellular region] (Caenorhabditis elegans)
FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Caenorhabditis elegans)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Caenorhabditis elegans)
as an output of
PDGF-AA clevage by Furin (Caenorhabditis elegans)
Inferred From
PDGF A homodimer [extracellular region]
(Homo sapiens)
PDGFA homodimer [extracellular region]
(Homo sapiens)
active PDGF-AA dimer [extracellular region]
(Homo sapiens)
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