Reactome | nhr-2 [nucleoplasm]

nhr-2 [nucleoplasm]

Stable Identifier

R-CEL-4719442-3

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

monoSUMO1-K283,K389-THRA-2, Q10902

Locations in the PathwayBrowser

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Metabolism of proteins (Caenorhabditis elegans)

- Post-translational protein modification (Caenorhabditis elegans)
  - SUMOylation (Caenorhabditis elegans)
    - SUMO E3 ligases SUMOylate target proteins (Caenorhabditis elegans)
      - SUMOylation of intracellular receptors (Caenorhabditis elegans)
        
        PIAS2-2 SUMOylates THRA with SUMO1 (Caenorhabditis elegans)
        
        Homologues of monoSUMO1-K283,K389-THRA-2 [nucleoplasm] (Caenorhabditis elegans)
        
        nhr-2 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q10902

Gene Names

nhr-2

Reference Genes

BioGPS Gene:172251 nhr-2

CTD Gene:172251 nhr-2

ENSEMBL:WBGene00003601

KEGG Gene (Caenorhabditis elegans):CELE_C32F10.6 nhr-2

Monarch:172251 nhr-2

NCBI Gene:172251 nhr-2

UCSC:Q10902 nhr-2

Wormbase:WBGene00003601

Reference Transcript

RefSeq:NM_059288.6 nhr-2

Other Identifiers

172251

173878_at

18465957

187812_s_at

193015_s_at

A_12_P105189

C32F10.6

C32F10.6_1123-1182_0.927_14_A

C32F10.6_649-708_0.899_25_B

C32F10.6_798-857_0.876_38_C

C32F10_6P00280

C32F10_6P00956

C32F10_6P01333

CE08543

CE_WBGene00003601_A

CE_WBGene00003601_C

CGZ0007157

GO:0003677

GO:0003700

GO:0006351

GO:0006355

GO:0008270

GO:0043565

GO:0140110

WBGene00003601

cea2.c.01126

Participates

as a member of

Homologues of monoSUMO1-K283,K389-THRA-2 [nucleoplasm] (Caenorhabditis elegans)

Other forms of this molecule

phospho-nhr-2 [nucleoplasm]

nhr-2 [nucleoplasm]

phospho-nhr-2 [nucleoplasm]

nhr-2 [nucleoplasm]

Inferred From

monoSUMO1-K283,K389-THRA-2 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 283 (in Homo sapiens)

Coordinate

283

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 389 (in Homo sapiens)

Coordinate

389

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_491689.4

PRO

Q10902

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03949	6	ABL2 [cytosol] (R-CEL-375998) phospho-p-Y393-ABL1 [cytosol] (R-CEL-9865161) p-Y226,Y393-ABL1 [nucleoplasm] (R-CEL-8985251) ABL1 [cytosol] (R-CEL-375987) ABL1 [nucleoplasm] (R-CEL-5686579) phospho-p-S456-ABL1 [nucleoplasm] (R-CEL-5686576)	0.488	2
UniProt:P50464	2	unc-97 [cytosol] (R-CEL-432859) unc-97 [cytosol] (R-CEL-446078)	0.488	2

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