Reactome | exo-1 [nucleoplasm]

exo-1 [nucleoplasm]

Stable Identifier

R-CEL-5357514

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

EXO1, O62245

Locations in the PathwayBrowser

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DNA Repair (Caenorhabditis elegans)

- DNA Double-Strand Break Repair (Caenorhabditis elegans)
  - Homology Directed Repair (Caenorhabditis elegans)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Caenorhabditis elegans)
      - Processing of DNA double-strand break ends (Caenorhabditis elegans)
        
        ATR phosphorylates RPA2 (Caenorhabditis elegans)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Caenorhabditis elegans)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Caenorhabditis elegans)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Caenorhabditis elegans)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Caenorhabditis elegans)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Caenorhabditis elegans)
        
        EXO1:BLM,WRN [nucleoplasm] (Caenorhabditis elegans)
        
        exo-1 [nucleoplasm] (Caenorhabditis elegans)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Caenorhabditis elegans)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Caenorhabditis elegans)
        
        EXO1:BLM,WRN [nucleoplasm] (Caenorhabditis elegans)
        
        exo-1 [nucleoplasm] (Caenorhabditis elegans)
- Mismatch Repair (Caenorhabditis elegans)
  - Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Caenorhabditis elegans)
    - EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Caenorhabditis elegans)
      - EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Caenorhabditis elegans)
        
        exo-1 [nucleoplasm] (Caenorhabditis elegans)
      - exo-1 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:O62245

Gene Names

exo-1

Reference Genes

BioGPS Gene:176765 exo-1

ENSEMBL:WBGene00009731

Monarch:176765 exo-1

NCBI Gene:176765 exo-1

UCSC:O62245 exo-1

Wormbase:WBGene00009731

Reference Transcript

RefSeq:NM_067369.4 exo-1

Other Identifiers

174428_s_at

174619_at

176765

18512121

192584_at

A_12_P101432

CE28728

CE_WBGene00009730_B

CE_WBGene00009731_A

CE_WBGene00009731_B

CE_WBGene00009731_C

CGZ0021923

CGZ0021926

F45G2.3

F45G2.3_411-470_0.832_53_C

F45G2.3_750-809_0.856_39_B

F45G2.3_877-936_0.882_27_A

F45G2_3P00428

F45G2_3P00680

F45G2_3P01029

GO:0003677

GO:0003824

GO:0004518

GO:0016787

GO:0035312

GO:0046872

GO:0140097

WBGene00009731

cea2.p.64814

Participates

as an input of

EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Caenorhabditis elegans)

as a component of

Inferred From

EXO1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_499770.1

PRO

O62245