Reactome | gex-2 [cytosol]

gex-2 [cytosol]

Stable Identifier

R-CEL-5672575

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

CYFIP1, O44518

Locations in the PathwayBrowser

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Immune System (Caenorhabditis elegans)

- Innate Immune System (Caenorhabditis elegans)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Caenorhabditis elegans)
    - Regulation of actin dynamics for phagocytic cup formation (Caenorhabditis elegans)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
        
        Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
        
        p-Y,S,T-WRC [cytosol] (Caenorhabditis elegans)
        
        gex-2 [cytosol] (Caenorhabditis elegans)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y-WRC [cytosol] (Caenorhabditis elegans)
        
        gex-2 [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
        
        p-Y,S,T-WRC [cytosol] (Caenorhabditis elegans)
        
        gex-2 [cytosol] (Caenorhabditis elegans)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y-WRC [cytosol] (Caenorhabditis elegans)
        
        gex-2 [cytosol] (Caenorhabditis elegans)
      - ABL phosphorylates WAVEs (Caenorhabditis elegans)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        WAVE Regulatory Complex [cytosol] (Caenorhabditis elegans)
        
        gex-2 [cytosol] (Caenorhabditis elegans)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y-WRC [cytosol] (Caenorhabditis elegans)
        
        gex-2 [cytosol] (Caenorhabditis elegans)
      - Detachment of WASP/WAVE (Caenorhabditis elegans)
        
        Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
        
        p-Y,S,T-WRC [cytosol] (Caenorhabditis elegans)
        
        gex-2 [cytosol] (Caenorhabditis elegans)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y-WRC [cytosol] (Caenorhabditis elegans)
        
        gex-2 [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
        
        p-Y,S,T-WRC [cytosol] (Caenorhabditis elegans)
        
        gex-2 [cytosol] (Caenorhabditis elegans)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y-WRC [cytosol] (Caenorhabditis elegans)
        
        gex-2 [cytosol] (Caenorhabditis elegans)
      - p-ERK phosphorylates WAVEs and ABI (Caenorhabditis elegans)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Caenorhabditis elegans)
        
        p-Y,S,T-WRC [cytosol] (Caenorhabditis elegans)
        
        gex-2 [cytosol] (Caenorhabditis elegans)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        p-Y-WRC [cytosol] (Caenorhabditis elegans)
        
        gex-2 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:O44518

Gene Names

gex-2

Reference Genes

BioGPS Gene:176885 gex-2

CTD Gene:176885 gex-2

ENSEMBL:WBGene00001579

KEGG:cel:CELE_F56A11.1 gex-2

Monarch:176885 gex-2

NCBI Gene:176885 gex-2

UCSC:O44518 gex-2

Wormbase:WBGene00001579

Wormbase:WBGene00001579 gex-2

Reference Transcript

RefSeq:NM_067548.4 gex-2

Other Identifiers

176885

GO:0000340

GO:0000902

GO:0003723

GO:0005515

GO:0005737

GO:0006417

GO:0007411

GO:0010172

GO:0016477

GO:0030031

GO:0030054

GO:0030833

GO:0031209

GO:0031267

GO:0043005

GO:0045202

GO:0048870

GO:1901046

GO:2000370

Participates

as a member of

RAC1 effectors [cytosol] (Caenorhabditis elegans)

as a candidate of

RHOG plasma membrane effectors [cytosol] (Caenorhabditis elegans)

as a component of

Other forms of this molecule

gex-2 [tertiary granule lumen]

gex-2 [specific granule lumen]

gex-2 [extracellular region]

gex-2 [secretory granule lumen]

gex-2 [cytosol]

Inferred From

CYFIP1,CYFIP2 [cytosol] (Homo sapiens)

CYFIP1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_499949.2

ENSEMBL

F56A11.1.1, WBGene00001579, F56A11.1.1

PRO

O44518

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