Reactome | mcm-3 [nucleoplasm]

mcm-3 [nucleoplasm]

Stable Identifier

R-CEL-68546

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

MCM3, Q9XVR7

Locations in the PathwayBrowser

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Cell Cycle (Caenorhabditis elegans)

- Cell Cycle, Mitotic (Caenorhabditis elegans)
  - Mitotic G1 phase and G1/S transition (Caenorhabditis elegans)
    - G1/S Transition (Caenorhabditis elegans)
      - Activation of the pre-replicative complex (Caenorhabditis elegans)
        
        Cdc45 associates with the pre-replicative complex at the origin (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
        
        Cdt1 is displaced from the pre-replicative complex. (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase alpha:primase binds at the origin (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon binds at the origin (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Caenorhabditis elegans)
        
        MCM10:pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
  - S Phase (Caenorhabditis elegans)
    - Synthesis of DNA (Caenorhabditis elegans)
      - Switching of origins to a post-replicative state (Caenorhabditis elegans)
        
        Mcm4,6,7 trimer forms and associates with the replication fork (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
        
        Orc1 removal from chromatin (Caenorhabditis elegans)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Caenorhabditis elegans)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)

DNA Replication (Caenorhabditis elegans)

- DNA Replication Pre-Initiation (Caenorhabditis elegans)
  - Activation of the pre-replicative complex (Caenorhabditis elegans)
    - Cdc45 associates with the pre-replicative complex at the origin (Caenorhabditis elegans)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
    - Cdt1 is displaced from the pre-replicative complex. (Caenorhabditis elegans)
      - MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
      - MCM10:pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
    - DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Caenorhabditis elegans)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
    - DNA polymerase alpha:primase binds at the origin (Caenorhabditis elegans)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
    - DNA polymerase epsilon binds at the origin (Caenorhabditis elegans)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
    - Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Caenorhabditis elegans)
      - MCM10:pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
      - pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
  - Assembly of the pre-replicative complex (Caenorhabditis elegans)
    - Formation of MCM2-7 complex (Caenorhabditis elegans)
      - MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
      - MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
    - MCM3 binds MCM5 (Caenorhabditis elegans)
      - MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
      - mcm-3 [nucleoplasm] (Caenorhabditis elegans)
- Synthesis of DNA (Caenorhabditis elegans)
  - Switching of origins to a post-replicative state (Caenorhabditis elegans)
    - Mcm4,6,7 trimer forms and associates with the replication fork (Caenorhabditis elegans)
      - MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
      - mcm-3 [nucleoplasm] (Caenorhabditis elegans)
    - Orc1 removal from chromatin (Caenorhabditis elegans)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Caenorhabditis elegans)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)
        
        mcm-3 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9XVR7

Gene Names

mcm-3

Reference Genes

BioGPS Gene:180010 mcm-3

ENSEMBL:WBGene00003155

Monarch:180010 mcm-3

NCBI Gene:180010 mcm-3

UCSC:Q9XVR7 mcm-3

Wormbase:WBGene00003155

Reference Transcript

RefSeq:NM_074305.5 mcm-3

Other Identifiers

171893_x_at

180010

18584177

193664_s_at

A_12_P108011

C25D7.6

C25D7.6_1912-1971_0.930_7_C

C25D7.6_2264-2323_0.936_5_B

C25D7.6_2349-2408_0.947_1_A

C25D7_6P01344

C25D7_6P01601

C25D7_6P02061

CE08392

CE_WBGene00003155_A

CE_WBGene00003155_C

CGZ0005882

GO:0003677

GO:0003824

GO:0005524

GO:0006260

GO:0006270

GO:0016787

GO:0016887

GO:0032508

GO:0042555

GO:0140657

WBGene00003155

cea2.p.109594

Participates

as an output of

Mcm4,6,7 trimer forms and associates with the replication fork (Caenorhabditis elegans)

as an input of

MCM3 binds MCM5 (Caenorhabditis elegans)

as a component of

MCM3:MCM5 [nucleoplasm] (Caenorhabditis elegans)

Inferred From

MCM3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_506706.1

PDB

8OUW

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