Reactome | MCM4 [nucleoplasm]

MCM4 [nucleoplasm]

Stable Identifier

R-CEL-68549

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

Q95XQ8

Locations in the PathwayBrowser

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Cell Cycle (Caenorhabditis elegans)

- Cell Cycle, Mitotic (Caenorhabditis elegans)
  - Mitotic G1 phase and G1/S transition (Caenorhabditis elegans)
    - G1/S Transition (Caenorhabditis elegans)
      - Activation of the pre-replicative complex (Caenorhabditis elegans)
        
        Cdc45 associates with the pre-replicative complex at the origin (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
        
        Cdt1 is displaced from the pre-replicative complex. (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase alpha:primase binds at the origin (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
        
        DNA polymerase epsilon binds at the origin (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Caenorhabditis elegans)
        
        MCM10:pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
  - S Phase (Caenorhabditis elegans)
    - Synthesis of DNA (Caenorhabditis elegans)
      - Switching of origins to a post-replicative state (Caenorhabditis elegans)
        
        Mcm4,6,7 trimer forms and associates with the replication fork (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
        
        Orc1 removal from chromatin (Caenorhabditis elegans)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Caenorhabditis elegans)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)

DNA Replication (Caenorhabditis elegans)

- DNA Replication Pre-Initiation (Caenorhabditis elegans)
  - Activation of the pre-replicative complex (Caenorhabditis elegans)
    - Cdc45 associates with the pre-replicative complex at the origin (Caenorhabditis elegans)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
    - Cdt1 is displaced from the pre-replicative complex. (Caenorhabditis elegans)
      - MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
      - MCM10:pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
    - DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Caenorhabditis elegans)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
    - DNA polymerase alpha:primase binds at the origin (Caenorhabditis elegans)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
    - DNA polymerase epsilon binds at the origin (Caenorhabditis elegans)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Caenorhabditis elegans)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        active pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
    - Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Caenorhabditis elegans)
      - MCM10:pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
      - pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
  - Assembly of the pre-replicative complex (Caenorhabditis elegans)
    - Formation of MCM2-7 complex (Caenorhabditis elegans)
      - MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
      - MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
    - MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Caenorhabditis elegans)
      - MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
      - MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
    - MCM4, MCM6 and MCM7 form a heterotrimer (Caenorhabditis elegans)
      - MCM4 [nucleoplasm] (Caenorhabditis elegans)
      - MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
- Synthesis of DNA (Caenorhabditis elegans)
  - Switching of origins to a post-replicative state (Caenorhabditis elegans)
    - Mcm4,6,7 trimer forms and associates with the replication fork (Caenorhabditis elegans)
      - MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
      - MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
    - Orc1 removal from chromatin (Caenorhabditis elegans)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Caenorhabditis elegans)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)
        
        pre-replicative complex [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2-7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)
        
        MCM4 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q95XQ8

Reference Genes

BioGPS Gene:171793

ENSEMBL:WBGene00003156

Monarch:171793

NCBI Gene:171793

UCSC:Q95XQ8

Wormbase:WBGene00003156

Reference Transcript

RefSeq:NM_058561.5

Other Identifiers

171793

176475_s_at

18475506

A_12_P112895

CE21767

CE_WBGene00003156_A

CE_WBGene00003156_C

CGZ0044977

CGZ0044978

GO:0003677

GO:0003678

GO:0003824

GO:0005524

GO:0006260

GO:0006270

GO:0016787

GO:0016887

GO:0032508

GO:0042555

GO:0140097

GO:0140657

WBGene00003156

Y39G10AR.14

Y39G10AR.14_1095-1154_0.831_40_A

Y39G10AR.14_1184-1243_0.781_82_C

Y39G10AR.14_652-711_0.816_44_B

Y39G10AR_14P01130

Y39G10AR_14P01483

Y39G10AR_14P02028

cea2.p.20801

Participates

as an input of

MCM4, MCM6 and MCM7 form a heterotrimer (Caenorhabditis elegans)

as a component of

MCM4:MCM6:MCM7 [nucleoplasm] (Caenorhabditis elegans)

Inferred From

MCM4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_490962.1

PRO

Q95XQ8

PDB

8OUW

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