Reactome | rpl-12 [cytosol]

rpl-12 [cytosol]

Stable Identifier

R-CEL-72408

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

RPL12, P61866

Locations in the PathwayBrowser

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Metabolism of RNA (Caenorhabditis elegans)

- Nonsense-Mediated Decay (NMD) (Caenorhabditis elegans)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Caenorhabditis elegans)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Caenorhabditis elegans)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rpl-12 [cytosol] (Caenorhabditis elegans)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rpl-12 [cytosol] (Caenorhabditis elegans)
    - SMG6 hydrolyzes mRNA with premature termination codon (Caenorhabditis elegans)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rpl-12 [cytosol] (Caenorhabditis elegans)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Caenorhabditis elegans)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rpl-12 [cytosol] (Caenorhabditis elegans)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rpl-12 [cytosol] (Caenorhabditis elegans)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Caenorhabditis elegans)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Caenorhabditis elegans)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rpl-12 [cytosol] (Caenorhabditis elegans)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rpl-12 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:P61866

Gene Names

rpl-12

Reference Genes

BioGPS Gene:178279 rpl-12

ENSEMBL:WBGene00004424

Monarch:178279 rpl-12

NCBI Gene:178279 rpl-12

UCSC:P61866 rpl-12

Wormbase:WBGene00004424

Reference Transcript

Other Identifiers

173407_s_at

175533_s_at

178279

18553858

18635585

A_12_P112752

A_12_P149980

A_12_P149981

A_12_P149982

A_12_P149983

CE17986

CE_WBGene00004424_A

CGZ0027053

CGZ0027059

GO:0003735

GO:0005198

GO:0005840

GO:0006412

GO:0043226

JC8.3

JC8.3a

JC8.3a_119-178_0.927_6_C

JC8.3a_347-406_0.971_1_A

JC8.3a_410-469_0.803_16_B

JC8_13P00074

JC8_3aP00181

JC8_3aP00197

JC8_3aP00307

JC8_3cP00029

JC8_3cP00033

JC8_3cP00093

WBGene00004424

cea2.c.29415

Participates

as a component of

Inferred From

RPL12 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001040960.1, NP_502542.1

PRO

P61866

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