Reactome | mpk-1 [nucleoplasm]

mpk-1 [nucleoplasm]

Stable Identifier

R-CEL-73724

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

MAPK3, P39745

Locations in the PathwayBrowser

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Immune System (Caenorhabditis elegans)

- Cytokine Signaling in Immune system (Caenorhabditis elegans)
  - Signaling by Interleukins (Caenorhabditis elegans)
    - Interleukin-17 signaling (Caenorhabditis elegans)
      - MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Caenorhabditis elegans)
        
        MAPK3 dimer [nucleoplasm] (Caenorhabditis elegans)
        
        mpk-1 [nucleoplasm] (Caenorhabditis elegans)
- Innate Immune System (Caenorhabditis elegans)
  - Toll-like Receptor Cascades (Caenorhabditis elegans)
    - Toll Like Receptor 10 (TLR10) Cascade (Caenorhabditis elegans)
      - MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Caenorhabditis elegans)
        
        MAPK3 dimer [nucleoplasm] (Caenorhabditis elegans)
        
        mpk-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 2 (TLR2) Cascade (Caenorhabditis elegans)
      - Toll Like Receptor TLR1:TLR2 Cascade (Caenorhabditis elegans)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Caenorhabditis elegans)
        
        MAPK3 dimer [nucleoplasm] (Caenorhabditis elegans)
        
        mpk-1 [nucleoplasm] (Caenorhabditis elegans)
      - Toll Like Receptor TLR6:TLR2 Cascade (Caenorhabditis elegans)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Caenorhabditis elegans)
        
        MAPK3 dimer [nucleoplasm] (Caenorhabditis elegans)
        
        mpk-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 3 (TLR3) Cascade (Caenorhabditis elegans)
      - MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Caenorhabditis elegans)
        
        MAPK3 dimer [nucleoplasm] (Caenorhabditis elegans)
        
        mpk-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 4 (TLR4) Cascade (Caenorhabditis elegans)
      - MyD88-independent TLR4 cascade (Caenorhabditis elegans)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Caenorhabditis elegans)
        
        MAPK3 dimer [nucleoplasm] (Caenorhabditis elegans)
        
        mpk-1 [nucleoplasm] (Caenorhabditis elegans)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Caenorhabditis elegans)
        
        MAPK3 dimer [nucleoplasm] (Caenorhabditis elegans)
        
        mpk-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 5 (TLR5) Cascade (Caenorhabditis elegans)
      - MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Caenorhabditis elegans)
        
        MAPK3 dimer [nucleoplasm] (Caenorhabditis elegans)
        
        mpk-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Caenorhabditis elegans)
      - MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Caenorhabditis elegans)
        
        MAPK3 dimer [nucleoplasm] (Caenorhabditis elegans)
        
        mpk-1 [nucleoplasm] (Caenorhabditis elegans)
    - Toll Like Receptor 9 (TLR9) Cascade (Caenorhabditis elegans)
      - MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Caenorhabditis elegans)
        
        MAPK3 dimer [nucleoplasm] (Caenorhabditis elegans)
        
        mpk-1 [nucleoplasm] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
  - Signaling by NTRKs (Caenorhabditis elegans)
    - Signaling by NTRK1 (TRKA) (Caenorhabditis elegans)
      - Nuclear Events (kinase and transcription factor activation) (Caenorhabditis elegans)
        
        ERK/MAPK targets (Caenorhabditis elegans)
        
        ERKs are inactivated (Caenorhabditis elegans)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Caenorhabditis elegans)
        
        MAPK3 dimer [nucleoplasm] (Caenorhabditis elegans)
        
        mpk-1 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:P39745

Gene Names

mpk-1

Reference Genes

BioGPS Gene:175545 mpk-1

CTD Gene:175545 mpk-1

ENSEMBL:WBGene00003401

KEGG:cel:CELE_F43C1.2 mpk-1

Monarch:175545 mpk-1

NCBI Gene:175545 mpk-1

UCSC:P39745 mpk-1

Wormbase:WBGene00003401

Wormbase:WBGene00003401 mpk-1

Reference Transcript

Other Identifiers

175545

GO:0000165

GO:0000166

GO:0001556

GO:0002164

GO:0003006

GO:0003824

GO:0004672

GO:0004674

GO:0004707

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0006355

GO:0006468

GO:0007166

GO:0007265

GO:0016301

GO:0016740

GO:0022412

GO:0022414

GO:0030154

GO:0032436

GO:0035556

GO:0040025

GO:0045944

GO:0046872

GO:0048468

GO:0048477

GO:0048513

GO:0048856

GO:0050830

GO:0051321

GO:0098542

GO:0106310

GO:0140096

Participates

as a component of

MAPK3 dimer [nucleoplasm] (Caenorhabditis elegans)

Other forms of this molecule

mpk-1 [ficolin-1-rich granule lumen]

mpk-1 [extracellular region]

mpk-1 [azurophil granule lumen]

phospho-mpk-1 [cytosol]

mpk-1 [nucleoplasm]

mpk-1 [cytosol]

phospho-mpk-1 [cytosol]

phospho-mpk-1 [nucleoplasm]

Inferred From

MAPK3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001022584.1, NP_001022583.1, NP_001366708.1

ENSEMBL

F43C1.2b.1, WBGene00003401, F43C1.2b.1

PRO

P39745

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O02289	2	phospho-gla-3 [cytosol] (R-CEL-450496-3) gla-3 [cytosol] (R-CEL-450562-3)	0.621	3
UniProt:Q17695 SPDL1			0.553	2
UniProt:Q19203 UNC98			0.553	2
UniProt:W10D9.3 O17285			0.553	2
UniProt:P91820 LST1			0.553	2
UniProt:Q9XUF2 Q9XUF2			0.553	2
UniProt:Q21229 Q21229			0.553	2
UniProt:P91829	2	nhr-69 [nucleoplasm] (R-CEL-211483-23) nhr-69 [nucleoplasm] (R-CEL-446162-23)	0.553	2

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