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PI3K [cytosol]
Stable Identifier
R-CEL-74693
Type
Complex
Species
Caenorhabditis elegans
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
GPVI-mediated activation cascade (Caenorhabditis elegans)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
Immune System (Caenorhabditis elegans)
Cytokine Signaling in Immune system (Caenorhabditis elegans)
Signaling by Interleukins (Caenorhabditis elegans)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Caenorhabditis elegans)
Regulation of signaling by CBL (Caenorhabditis elegans)
CBL ubiquitinates PI3K (Caenorhabditis elegans)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Caenorhabditis elegans)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
Metabolism (Caenorhabditis elegans)
Metabolism of lipids (Caenorhabditis elegans)
Phospholipid metabolism (Caenorhabditis elegans)
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Caenorhabditis elegans)
PIK3C(1) [cytosol] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Caenorhabditis elegans)
PIK3C(1) [cytosol] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
Activator:PI3K [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
PI3K:p-ERBB4cyt1 [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
Activator:PI3K [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
PI3K:p-ERBB4cyt1 [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
RAC1,RAC2,RHOG activate PI3K (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
RAS:GTP binds PI3K (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
p21 RAS:GTP:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (q) signalling events (Caenorhabditis elegans)
G alpha (q) inhibits PI3K alpha (Caenorhabditis elegans)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
Extra-nuclear estrogen signaling (Caenorhabditis elegans)
PTK2 is recruited to methylated ESR1 (Caenorhabditis elegans)
Me260-ESR1:STRN:ESTG: MyrG-pY419 SRC:PI3Kalpha:pY-PTK2 [plasma membrane] (Caenorhabditis elegans)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by ALK (Caenorhabditis elegans)
PI3K synthesizes PIP3 downstream of ALK (Caenorhabditis elegans)
Active ALK:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
Signaling by EGFR (Caenorhabditis elegans)
GAB1 signalosome (Caenorhabditis elegans)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
Signaling by ERBB2 (Caenorhabditis elegans)
PI3K events in ERBB2 signaling (Caenorhabditis elegans)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Caenorhabditis elegans)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
Signaling by ERBB4 (Caenorhabditis elegans)
PI3K events in ERBB4 signaling (Caenorhabditis elegans)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Caenorhabditis elegans)
PI3K:p-ERBB4cyt1 [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
Signaling by MET (Caenorhabditis elegans)
MET activates PI3K/AKT signaling (Caenorhabditis elegans)
MET bound PI3K generates PIP3 (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
Phosphorylated GAB1 recruits PI3K to MET (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
Signaling by PDGF (Caenorhabditis elegans)
Downstream signal transduction (Caenorhabditis elegans)
PI3-kinase binds to the active receptor (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
Signaling by SCF-KIT (Caenorhabditis elegans)
Synthesis of PIP3 from PIP2 by PI3K (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
p-AXL binds PI3K (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
Signaling by Rho GTPases (Caenorhabditis elegans)
RHO GTPase cycle (Caenorhabditis elegans)
RAC1 GTPase cycle (Caenorhabditis elegans)
RAC1 binds effectors at the plasma membrane (Caenorhabditis elegans)
RAC1 effectors [cytosol] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
RAC1:GTP:RAC1 effectors [plasma membrane] (Caenorhabditis elegans)
RAC1 effectors [cytosol] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
RAC2 GTPase cycle (Caenorhabditis elegans)
RAC2 binds effectors at the plasma membrane (Caenorhabditis elegans)
RAC2 plasma membrane effectors [cytosol] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Caenorhabditis elegans)
RAC2 plasma membrane effectors [cytosol] (Caenorhabditis elegans)
PI3K [cytosol] (Caenorhabditis elegans)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
aap-1 [cytosol]
(Caenorhabditis elegans)
age-1 [cytosol]
(Caenorhabditis elegans)
Participates
as a member of
RAC2 plasma membrane effectors [cytosol] (Caenorhabditis elegans)
RAC1 effectors [cytosol] (Caenorhabditis elegans)
PIK3C(1) [cytosol] (Caenorhabditis elegans)
as a component of
Active ALK:PI3K [plasma membrane] (Caenorhabditis elegans)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Caenorhabditis elegans)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Caenorhabditis elegans)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Caenorhabditis elegans)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Caenorhabditis elegans)
p21 RAS:GTP:PI3K [plasma membrane] (Caenorhabditis elegans)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Caenorhabditis elegans)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Caenorhabditis elegans)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Caenorhabditis elegans)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Caenorhabditis elegans)
PI3K:p-ERBB4cyt1 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Caenorhabditis elegans)
as an input of
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Caenorhabditis elegans)
Phosphorylated GAB1 recruits PI3K to MET (Caenorhabditis elegans)
G alpha (q) inhibits PI3K alpha (Caenorhabditis elegans)
RAS:GTP binds PI3K (Caenorhabditis elegans)
p-AXL binds PI3K (Caenorhabditis elegans)
RAC1,RAC2,RHOG activate PI3K (Caenorhabditis elegans)
PI3-kinase binds to the active receptor (Caenorhabditis elegans)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Caenorhabditis elegans)
Inferred From
PI3K alpha, gamma [cytosol]
(Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol]
(Homo sapiens)
PI3K alpha, beta, gamma [cytosol]
(Homo sapiens)
PI3K alpha [cytosol]
(Homo sapiens)
PIK3CA:PIK3R1 [cytosol]
(Homo sapiens)
PI3K [cytosol]
(Homo sapiens)
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