Reactome | phospho-ama-1 [nucleoplasm]

phospho-ama-1 [nucleoplasm]

Stable Identifier

R-CEL-77100

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

p-S5-POLR2A, P16356

Locations in the PathwayBrowser

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Gene expression (Transcription) (Caenorhabditis elegans)

- RNA Polymerase II Transcription (Caenorhabditis elegans)
  - RNA Pol II CTD phosphorylation and interaction with CE (Caenorhabditis elegans)
    - Activation of GT (Caenorhabditis elegans)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
    - Phosphorylation (Ser5) of RNA pol II CTD (Caenorhabditis elegans)
      - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
    - RNA Polymerase II CTD (phosphorylated) binds to CE (Caenorhabditis elegans)
      - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
    - SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Caenorhabditis elegans)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
  - RNA Polymerase II Pre-transcription Events (Caenorhabditis elegans)
    - Abortive termination of early transcription elongation by DSIF:NELF (Caenorhabditis elegans)
      - DSIF:NELF:early elongation complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
  - RNA Polymerase II Transcription Elongation (Caenorhabditis elegans)
    - Formation of the Early Elongation Complex (Caenorhabditis elegans)
      - DSIF complex binds to RNA Pol II (hypophosphorylated) (Caenorhabditis elegans)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
      - Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Caenorhabditis elegans)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
        
        capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)

Metabolism of RNA (Caenorhabditis elegans)

- Processing of Capped Intron-Containing Pre-mRNA (Caenorhabditis elegans)
  - mRNA Splicing (Caenorhabditis elegans)
    - mRNA Splicing - Major Pathway (Caenorhabditis elegans)
      - Formation of Exon Junction Complex (Caenorhabditis elegans)
        
        Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
        
        pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
      - Lariat Formation and 5'-Splice Site Cleavage (Caenorhabditis elegans)
        
        Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
- mRNA Capping (Caenorhabditis elegans)
  - Activation of GT (Caenorhabditis elegans)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
  - Capping complex formation (Caenorhabditis elegans)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
    - Capping complex (initial) [nucleoplasm] (Caenorhabditis elegans)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
  - Dissociation of transcript with 5'-GMP from GT (Caenorhabditis elegans)
    - Capping complex (GpppN..) [nucleoplasm] (Caenorhabditis elegans)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
    - Capping complex (with freed 5'- GMP) [nucleoplasm] (Caenorhabditis elegans)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
  - Formation of the CE:GMP intermediate complex (Caenorhabditis elegans)
    - Capping complex (intermediate) [nucleoplasm] (Caenorhabditis elegans)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Caenorhabditis elegans)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
    - Capping complex (hydrolyzed) [nucleoplasm] (Caenorhabditis elegans)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
  - Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Caenorhabditis elegans)
    - Capping complex (hydrolyzed) [nucleoplasm] (Caenorhabditis elegans)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
    - Capping complex (initial) [nucleoplasm] (Caenorhabditis elegans)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
  - Methylation of GMP-cap by RNA Methyltransferase (Caenorhabditis elegans)
    - Capping complex (with freed 5'- GMP) [nucleoplasm] (Caenorhabditis elegans)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
    - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
  - RNA Polymerase II CTD (phosphorylated) binds to CE (Caenorhabditis elegans)
    - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
  - Recognition and binding of the mRNA cap by the cap-binding complex (Caenorhabditis elegans)
    - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
    - capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Caenorhabditis elegans)
      - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
  - SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Caenorhabditis elegans)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
  - Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Caenorhabditis elegans)
    - Capping complex (intermediate) [nucleoplasm] (Caenorhabditis elegans)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Caenorhabditis elegans)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)
    - Capping complex (GpppN..) [nucleoplasm] (Caenorhabditis elegans)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by Nuclear Receptors (Caenorhabditis elegans)
  - ESR-mediated signaling (Caenorhabditis elegans)
    - Estrogen-dependent gene expression (Caenorhabditis elegans)
      - p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Caenorhabditis elegans)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:P16356

Gene Names

ama-1

Reference Genes

BioGPS Gene:177190 ama-1

ENSEMBL:WBGene00000123

KEGG Gene (Caenorhabditis elegans):CELE_F36A4.7 ama-1

Monarch:177190 ama-1

NCBI Gene:177190 ama-1

UCSC:P16356 ama-1

Wormbase:WBGene00000123

Reference Transcript

RefSeq:NM_068122.6 ama-1

Other Identifiers

177190

18537760

191893_s_at

A_12_P112899

CE28300

CE_WBGene00000123_A

CE_WBGene00000123_B

CE_WBGene00000123_C

CGZ0019925

F36A4.7

F36A4.7_3911-3970_0.837_10_B

F36A4.7_4087-4146_0.829_12_C

F36A4.7_5533-5592_0.963_1_A

F36A4_7P04202

F36A4_7P04513

F36A4_7P05403

GO:0001055

GO:0003674

GO:0003677

GO:0003899

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005665

GO:0005694

GO:0006351

GO:0006366

GO:0007369

GO:0008150

GO:0009058

GO:0009790

GO:0009792

GO:0016740

GO:0016779

GO:0032991

GO:0034641

GO:0035327

GO:0042789

GO:0043167

GO:0043226

GO:0045893

GO:0046872

GO:0048856

GO:2000543

WBGene00000123

cea2.p.91959

Participates

as a component of

Other forms of this molecule

phospho-ama-1 [nucleoplasm]

ama-1 [nucleoplasm]

Inferred From

p-S5-POLR2A [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 5 (in Homo sapiens)

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_500523.4

PRO

P16356

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