Reactome | gar-3 [clathrin-coated endocytic vesicle membrane]

gar-3 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-CEL-8869085

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

CHRM2, Q9U7D5

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - Clathrin-mediated endocytosis (Caenorhabditis elegans)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        gar-3 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        gar-3 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        gar-3 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        gar-3 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        gar-3 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        gar-3 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        gar-3 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
    - RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        gar-3 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9U7D5

Gene Names

gar-3

Reference Genes

BioGPS Gene:179962 gar-3

CTD Gene:179962 gar-3

ENSEMBL:WBGene00001519

KEGG:cel:CELE_Y40H4A.1 gar-3

Monarch:179962 gar-3

NCBI Gene:179962 gar-3

UCSC:Q9U7D5 gar-3

Wormbase:WBGene00001519

Reference Transcript

Other Identifiers

175791_at

179962

18599461

192386_s_at

192479_s_at

A_12_P108923

A_12_P153005

A_12_P153006

CE27783

CE_WBGene00001519_A

CGZ0045124

GO:0001508

GO:0004930

GO:0004993

GO:0005886

GO:0007186

GO:0007187

GO:0007197

GO:0007213

GO:0007268

GO:0008227

GO:0009410

GO:0014057

GO:0016020

GO:0016907

GO:0023052

GO:0030425

GO:0043051

GO:0045202

GO:0060089

GO:0098664

GO:1902474

WBGene00001519

Y40H4A.1

Y40H4A.1b_1581-1640_0.924_17_C

Y40H4A.1b_1713-1772_0.962_1_B

Y40H4A.1b_1794-1853_0.962_2_A

Y40H4A_1aP00473

Y40H4A_1aP00887

Y40H4A_1aP01499

Y40H4A_1bP00790

Y40H4A_1bP00794

cea2.c.39659

Participates

as a member of

ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

Other forms of this molecule

gar-3 [plasma membrane]

Inferred From

CHRM2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_001024236.1, NP_001024235.1

ENSEMBL

Y40H4A.1b.1

PRO

Q9U7D5

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