Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
cul-2 [cytosol]
Stable Identifier
R-CEL-8952511
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
cytosol
Synonyms
G76-NEDD8-K689-CUL2, Q17390
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Neddylation (Caenorhabditis elegans)
26S proteasome degrades HIFalpha (Caenorhabditis elegans)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Caenorhabditis elegans)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
NEDD8-CRL2 E3 ligase complex [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Caenorhabditis elegans)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Caenorhabditis elegans)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Caenorhabditis elegans)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Caenorhabditis elegans)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:Q17390
Gene Names
cul-2
Reference Genes
BioGPS Gene:176806 cul-2
CTD Gene:176806 cul-2
ENSEMBL:WBGene00000837
Monarch:176806 cul-2
NCBI Gene:176806 cul-2
UCSC:Q17390 cul-2
Wormbase:WBGene00000837
Reference Transcript
RefSeq:NM_001027837.1 cul-2
RefSeq:NM_001027838.2 cul-2
RefSeq:NM_001027836.2 cul-2
Other Identifiers
175606_at
176806
18519775
18519788
192809_s_at
193583_at
A_12_P108125
A_12_P120099
A_12_P158860
A_12_P158861
A_12_P158862
A_12_P158863
CE16730
CE32774
CE32777
CE_WBGene00000837_A
CE_WBGene00000837_B
CE_WBGene00000837_C
CE_WBGene00000878_A
CGZ0056954
GO:0006511
GO:0030163
GO:0031461
GO:0031625
WBGene00000837
WBGene00000878
ZK520.4
ZK520.4a
ZK520.4a_2010-2069_0.942_1_A
ZK520.4a_2455-2514_0.942_2_B
ZK520.4a_733-792_0.818_95_C
ZK520.4c
ZK520.4d
ZK520.5
ZK520_4aP01090
ZK520_4aP01404
ZK520_4aP01993
cea2.d.07551
cea2.d.49256
cea2.d.49288
cea2.d.49292
cea2.d.49323
Participates
as a component of
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
NEDD8-CRL2 E3 ligase complex [cytosol] (Caenorhabditis elegans)
Other forms of this molecule
cul-2 [nucleoplasm]
cul-2 [cytosol]
Inferred From
G76-NEDD8-K689-CUL2 [cytosol]
(Homo sapiens)
Modified Residues
Name
neddylated lysine (monoNEDD8 [cytosol]) at 689 (in Homo sapiens)
Coordinate
689
Modification
monoNEDD8 [cytosol]
PsiMod Name
neddylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein.
Cross References
RefSeq
NP_001023007.1
,
NP_001023008.1
,
NP_001023009.1
PRO
Q17390
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BKS1
2
elc-1 [nucleoplasm]
(R-CEL-112422)
elc-1 [cytosol]
(R-CEL-180535)
0.589
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text