Reactome | wdr-5.3 [cytosol]

wdr-5.3 [cytosol]

Stable Identifier

R-CEL-976035

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

FBXW11, Q23256

Locations in the PathwayBrowser

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Immune System (Caenorhabditis elegans)

- Adaptive Immune System (Caenorhabditis elegans)
  - Class I MHC mediated antigen processing & presentation (Caenorhabditis elegans)
    - Antigen processing: Ubiquitination & Proteasome degradation (Caenorhabditis elegans)
      - Interaction of E3 with substrate and E2-Ub complex (Caenorhabditis elegans)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.3 [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.3 [cytosol] (Caenorhabditis elegans)
      - Polyubiquitination of substrate (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.3 [cytosol] (Caenorhabditis elegans)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.3 [cytosol] (Caenorhabditis elegans)
        
        E3:Ub:substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.3 [cytosol] (Caenorhabditis elegans)
      - Release of E3 from polyubiquitinated substrate (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.3 [cytosol] (Caenorhabditis elegans)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.3 [cytosol] (Caenorhabditis elegans)
      - Transfer of Ub from E2 to substrate and release of E2 (Caenorhabditis elegans)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.3 [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.3 [cytosol] (Caenorhabditis elegans)
        
        E3:Ub:substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.3 [cytosol] (Caenorhabditis elegans)

Metabolism of proteins (Caenorhabditis elegans)

- Post-translational protein modification (Caenorhabditis elegans)
  - Neddylation (Caenorhabditis elegans)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Caenorhabditis elegans)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.3 [cytosol] (Caenorhabditis elegans)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.3 [cytosol] (Caenorhabditis elegans)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Caenorhabditis elegans)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Caenorhabditis elegans)
        
        CRL E3 ubiquitin ligases [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.3 [cytosol] (Caenorhabditis elegans)
      - CRL E3 ubiquitin ligases [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.3 [cytosol] (Caenorhabditis elegans)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Caenorhabditis elegans)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.3 [cytosol] (Caenorhabditis elegans)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.3 [cytosol] (Caenorhabditis elegans)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Caenorhabditis elegans)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.3 [cytosol] (Caenorhabditis elegans)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.3 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q23256

Gene Names

wdr-5.3

Reference Genes

BioGPS Gene:179489 wdr-5.3

CTD Gene:179489 wdr-5.3

ENSEMBL:WBGene00013862

KEGG Gene (Caenorhabditis elegans):CELE_ZC302.2 wdr-5.3

Monarch:179489 wdr-5.3

NCBI Gene:179489 wdr-5.3

UCSC:Q23256 wdr-5.3

Wormbase:WBGene00013862

Reference Transcript

RefSeq:NM_001029128.3 wdr-5.3

Other Identifiers

179489

18580737

18635621

192759_at

A_12_P109770

CE06574

CE_WBGene00013862_A

CE_WBGene00013862_B

CE_WBGene00013862_C

CGZ0055716

CGZ0055717

GO:0005515

WBGene00013862

ZC302.2

ZC302.2a_1054-1113_0.927_4_C

ZC302.2a_1389-1448_0.949_1_A

ZC302.2a_985-1044_0.926_5_B

ZC302_2aP00138

ZC302_2aP00727

ZC302_2aP01088

cea2.p.130869

Participates

as a member of

Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)

Inferred From

FBXW11 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001024299.1

PRO

Q23256

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