Reactome | wdr-5.2 [cytosol]

wdr-5.2 [cytosol]

Stable Identifier

R-CEL-976035-2

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

FBXW11, Q93847

Locations in the PathwayBrowser

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Immune System (Caenorhabditis elegans)

- Adaptive Immune System (Caenorhabditis elegans)
  - Class I MHC mediated antigen processing & presentation (Caenorhabditis elegans)
    - Antigen processing: Ubiquitination & Proteasome degradation (Caenorhabditis elegans)
      - Interaction of E3 with substrate and E2-Ub complex (Caenorhabditis elegans)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.2 [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.2 [cytosol] (Caenorhabditis elegans)
      - Polyubiquitination of substrate (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.2 [cytosol] (Caenorhabditis elegans)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.2 [cytosol] (Caenorhabditis elegans)
        
        E3:Ub:substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.2 [cytosol] (Caenorhabditis elegans)
      - Release of E3 from polyubiquitinated substrate (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.2 [cytosol] (Caenorhabditis elegans)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.2 [cytosol] (Caenorhabditis elegans)
      - Transfer of Ub from E2 to substrate and release of E2 (Caenorhabditis elegans)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.2 [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.2 [cytosol] (Caenorhabditis elegans)
        
        E3:Ub:substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.2 [cytosol] (Caenorhabditis elegans)

Metabolism of proteins (Caenorhabditis elegans)

- Post-translational protein modification (Caenorhabditis elegans)
  - Neddylation (Caenorhabditis elegans)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Caenorhabditis elegans)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.2 [cytosol] (Caenorhabditis elegans)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.2 [cytosol] (Caenorhabditis elegans)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Caenorhabditis elegans)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Caenorhabditis elegans)
        
        CRL E3 ubiquitin ligases [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.2 [cytosol] (Caenorhabditis elegans)
      - CRL E3 ubiquitin ligases [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.2 [cytosol] (Caenorhabditis elegans)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Caenorhabditis elegans)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.2 [cytosol] (Caenorhabditis elegans)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.2 [cytosol] (Caenorhabditis elegans)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Caenorhabditis elegans)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.2 [cytosol] (Caenorhabditis elegans)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        wdr-5.2 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q93847

Gene Names

wdr-5.2

Reference Genes

BioGPS Gene:181540 wdr-5.2

CTD Gene:181540 wdr-5.2

ENSEMBL:WBGene00010572

KEGG Gene (Caenorhabditis elegans):CELE_K04G11.4 wdr-5.2

Monarch:181540 wdr-5.2

NCBI Gene:181540 wdr-5.2

UCSC:Q93847 wdr-5.2

Wormbase:WBGene00010572

Reference Transcript

RefSeq:NM_077993.3 wdr-5.2

Other Identifiers

181540

18612968

193788_at

A_12_P101435

CE11748

CE_WBGene00010572_A

CE_WBGene00010572_B

CGZ0027828

GO:0005515

K04G11.4

K04G11.4_984-1043_0.962_1_A

K04G11_4P00092

K04G11_4P00336

K04G11_4P01064

WBGene00010572

cea2.p.149205

Participates

as a member of

Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)

Inferred From

FBXW11 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_510394.1

PRO

Q93847

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