Reactome | lis-1 [cytosol]

lis-1 [cytosol]

Stable Identifier

R-CEL-976035-3

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

FBXW11, Q9NDC9

Locations in the PathwayBrowser

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Immune System (Caenorhabditis elegans)

- Adaptive Immune System (Caenorhabditis elegans)
  - Class I MHC mediated antigen processing & presentation (Caenorhabditis elegans)
    - Antigen processing: Ubiquitination & Proteasome degradation (Caenorhabditis elegans)
      - Interaction of E3 with substrate and E2-Ub complex (Caenorhabditis elegans)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        lis-1 [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        lis-1 [cytosol] (Caenorhabditis elegans)
      - Polyubiquitination of substrate (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        lis-1 [cytosol] (Caenorhabditis elegans)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        lis-1 [cytosol] (Caenorhabditis elegans)
        
        E3:Ub:substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        lis-1 [cytosol] (Caenorhabditis elegans)
      - Release of E3 from polyubiquitinated substrate (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        lis-1 [cytosol] (Caenorhabditis elegans)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        lis-1 [cytosol] (Caenorhabditis elegans)
      - Transfer of Ub from E2 to substrate and release of E2 (Caenorhabditis elegans)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        lis-1 [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        lis-1 [cytosol] (Caenorhabditis elegans)
        
        E3:Ub:substrate [cytosol] (Caenorhabditis elegans)
        
        E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        lis-1 [cytosol] (Caenorhabditis elegans)

Metabolism of proteins (Caenorhabditis elegans)

- Post-translational protein modification (Caenorhabditis elegans)
  - Neddylation (Caenorhabditis elegans)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Caenorhabditis elegans)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        lis-1 [cytosol] (Caenorhabditis elegans)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        lis-1 [cytosol] (Caenorhabditis elegans)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Caenorhabditis elegans)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Caenorhabditis elegans)
        
        CRL E3 ubiquitin ligases [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        lis-1 [cytosol] (Caenorhabditis elegans)
      - CRL E3 ubiquitin ligases [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        lis-1 [cytosol] (Caenorhabditis elegans)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Caenorhabditis elegans)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        lis-1 [cytosol] (Caenorhabditis elegans)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        lis-1 [cytosol] (Caenorhabditis elegans)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Caenorhabditis elegans)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        lis-1 [cytosol] (Caenorhabditis elegans)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Caenorhabditis elegans)
        
        SCF E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
        
        F-box protein [cytosol] (Caenorhabditis elegans)
        
        Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)
        
        lis-1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9NDC9

Gene Names

lis-1

Reference Genes

BioGPS Gene:176758 lis-1

ENSEMBL:WBGene00003047

KEGG Gene (Caenorhabditis elegans):CELE_T03F6.5 lis-1

Monarch:176758 lis-1

NCBI Gene:176758 lis-1

UCSC:Q9NDC9 lis-1

Wormbase:WBGene00003047

Reference Transcript

RefSeq:NM_067354.5 lis-1

Other Identifiers

175630_at

176758

18527022

18527048

193632_s_at

A_12_P104837

CE29339

CE_WBGene00003047_A

CGZ0032956

GO:0005515

T03F6.5

T03F6.5_1086-1145_0.964_1_A

T03F6.5_937-996_0.940_5_B

T03F6.5_997-1056_0.940_4_C

T03F6.9_179-238_0.818_30_B

T03F6.9_60-119_0.908_15_A

T03F6_5P00268

T03F6_5P00373

T03F6_5P00657

WBGene00003047

cea2.c.22602

Participates

as a member of

Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

lis-1 [cytosol]

Inferred From

FBXW11 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_499755.1

PRO

Q9NDC9

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