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p-Y-IRS1,p-Y-IRS2 [cytosol]
Stable Identifier
R-CFA-112322
Type
Set [DefinedSet]
Species
Canis familiaris
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
RAS GEFs [plasma membrane] (Canis familiaris)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor signalling cascade (Canis familiaris)
IRS activation (Canis familiaris)
Dissociation of IRS-P from insulin receptor (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
Phosphorylation of IRS (Canis familiaris)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
SOS-mediated signalling (Canis familiaris)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Canis familiaris)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
Signal attenuation (Canis familiaris)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Canis familiaris)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Canis familiaris)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
PI3K/AKT activation (Canis familiaris)
Active IRS recruits PI3K to the plasma membrane and activates it (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
IGF1R signaling cascade (Canis familiaris)
IRS-related events triggered by IGF1R (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
SOS-mediated signalling (Canis familiaris)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Canis familiaris)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
Participants
members
phospho-IRS1 [cytosol]
(Canis familiaris)
phospho-IRS2 [cytosol]
(Canis familiaris)
Participates
as an input of
p-Y-IRS1,p-Y-IRS2 bind PI3K (Canis familiaris)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Canis familiaris)
as a component of
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Canis familiaris)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Canis familiaris)
as an output of
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Canis familiaris)
Dissociation of IRS-P from insulin receptor (Canis familiaris)
Inferred From
p-Y-IRS1,p-Y-IRS2 [cytosol]
(Homo sapiens)
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