Reactome | P-TEFb complex [nucleoplasm]

P-TEFb complex [nucleoplasm]

Stable Identifier

R-CFA-112431

Type

Complex

Species

Canis familiaris

Compartment

nucleoplasm

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

CCNT1,CCNT2,CCNK [nucleoplasm] (Canis familiaris)
CDK9 [nucleoplasm] (Canis familiaris)

Participates

as an output of

Elongating transcript encounters a lesion in the template (Canis familiaris)
Formation of P-TEFb complex (Canis familiaris)

as an input of

General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Canis familiaris)
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Canis familiaris)

as a component of

RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Canis familiaris)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Canis familiaris)
Aborted elongation complex after arrest [nucleoplasm] (Canis familiaris)
Paused processive elongation complex [nucleoplasm] (Canis familiaris)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Canis familiaris)
Elongation complex prior to separation [nucleoplasm] (Canis familiaris)
Processive elongation complex [nucleoplasm] (Canis familiaris)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Canis familiaris)
CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Canis familiaris)
Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Canis familiaris)

as a member of

CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Canis familiaris)

Inferred From

P-TEFb complex [nucleoplasm] (Homo sapiens)