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phospho-CDK4 [nucleoplasm]
Stable Identifier
R-CFA-113830
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
p-T172-CDK4, A0A8I3NU36
Locations in the PathwayBrowser
Expand all
Cell Cycle (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
Mitotic G1 phase and G1/S transition (Canis familiaris)
G1 Phase (Canis familiaris)
Cyclin D associated events in G1 (Canis familiaris)
CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND1 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND2 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND3 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND1 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND2 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND3 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND1 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND2 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND3 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND1 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND2:CDK4 inhibitors (CCND2) [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND2 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND3:CDK4 inhibitors (CCND3) [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND3 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND1 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND2 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND3 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
Drug-mediated inhibition of CDK4/CDK6 activity (Canis familiaris)
CDK4 inhibitors bind CDK4 (Canis familiaris)
p-T172-CDK4:CCND [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND1 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND2 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND3 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND1 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND2:CDK4 inhibitors (CCND2) [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND2 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND3:CDK4 inhibitors (CCND3) [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND3 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Canis familiaris)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND1 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND2 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND3 [nucleoplasm] (Canis familiaris)
phospho-CDK4 [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NU36
Gene Names
CDK4
Reference Genes
BioGPS Gene:481131 CDK4
ENSEMBL:ENSCAFG00845013840.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845013840.1 CDK4
KEGG Gene (Canis lupus familiaris):481131 CDK4
Monarch:481131 CDK4
NCBI Gene:481131 CDK4
Reference Transcript
RefSeq:XM_844780.4 CDK4
Other Identifiers
481131
Cfa.21129.1.S1_at
CfaAffx.1381.1.S1_s_at
GO:0000082
GO:0000166
GO:0000278
GO:0000307
GO:0000785
GO:0003824
GO:0004672
GO:0004674
GO:0004693
GO:0005524
GO:0005634
GO:0005635
GO:0005654
GO:0005667
GO:0005694
GO:0005730
GO:0005829
GO:0005923
GO:0006468
GO:0007165
GO:0008284
GO:0009410
GO:0010468
GO:0010971
GO:0016301
GO:0016740
GO:0023052
GO:0030332
GO:0031965
GO:0036211
GO:0043226
GO:0048146
GO:0051726
GO:0061469
GO:0071222
GO:0071353
GO:0097128
GO:0097129
GO:0097130
GO:0140096
GO:1904628
GO:1904637
Participates
as a component of
p-T172-CDK4:CCND1 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND3 [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND2 [nucleoplasm] (Canis familiaris)
as a member of
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Canis familiaris)
Other forms of this molecule
CDK4 [cytosol]
CDK4 [nucleoplasm]
Inferred From
p-T172-CDK4 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 172 (in Homo sapiens)
Coordinate
172
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
XP_849873.1
OpenTargets
ENSG00000135446
Ensembl
ENSCAFP00845019455
,
ENSCAFG00845013840
,
ENSCAFT00845024719
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